Title
Prepubertal Use of Long-Term GnRH Agonists in Dogs: Current Knowledge and Recommendations
Language
English
Description (en)
The search for an alternative approach of estrus control (induction or suppression) in dogs is an important issue and the use of slow GnRH agonist-releasing implants has been the subject of frequent research in recent years. Studies to date demonstrate that the short- and long-term effects of deslorelin implants applicated at different time points of the prepubertal period are similar to those of adult dogs; however, there are important differences. The age of the prepubertal bitch and the dosage appear to be the main determinants of the response to deslorelin, as well as the individual metabolism of the bitch. Recent studies reported that the deslorelin-mediated long-term delay of puberty does not have negative carry-over effects on subsequent ovarian functionality, serum steroid hormone concentrations, uterine health, and fertility; however, more molecular studies are needed to determine the effects of application time of GnRH agonists on hormone concentrations and peripheral receptor expression. Furthermore, the long-term effects of delay of puberty with deslorelin on joint health, tumor development, the immune system, and social behavior deserve further investigations.
Keywords (en)
Female Dogs; Reproductive Function; Deslorelin Implants; Puberty; Fertility; Bitches; Suppression; Receptor; Release; Contraception
DOI
10.3390/ani12172267
Author of the digital object
Sabine  Schäfer-Somi  (University of Veterinary Medicine Vienna)
Duygu  Kaya  (University of Kafkas)
Selim  Aslan  (Near East University)
Format
application/pdf
Size
265.9 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Animals
Pages or Volume
15
Volume
12
Number
17
Publisher
MDPI
Publication Date
2022
Content
Details
Object type
PDFDocument
Format
application/pdf
Created
18.09.2023 02:21:33
This object is in collection
Metadata
Veterinärmedizinische Universität Wien (Vetmeduni) | Veterinärplatz 1 | 1210 Wien - Österreich | T +43 1 25077 1414 | Web: vetmeduni.ac.at