{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore#","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/0.1\/","frap":"http:\/\/purl.org\/cerif\/frapo\/","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","oaire":"http:\/\/namespace.openaire.eu\/schema\/oaire\/","oefos2012":"https:\/\/vocabs.acdh.oeaw.ac.at\/oefosdisciplines\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdaa":"http:\/\/rdaregistry.info\/Elements\/a\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"http:\/\/www.w3.org\/2000\/01\/rdf-schema#","relators":"http:\/\/id.loc.gov\/vocabulary\/relators\/","role":"http:\/\/id.loc.gov\/vocabulary\/relators\/","role:assessor":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/assessor"},"role:aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"},"role:dgs":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/dgs"},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl#","vra":"http:\/\/purl.org\/vra\/"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:5537","bf:note":[{"@type":"bf:Note","skos:prefLabel":[{"@language":"eng","@value":"Diploma thesis - University of Veterinary Medicine Vienna - 2026\n\nThe full text is only available to university members. Please log in!"}]},{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"The biological functions of androgens during gestation are not well researched yet, as androgens are often only regarded as precursors of oestrogens. Every day enormous amounts of faeces are excreted by livestock, thus faecal androgen metabolites could pose an ecological risk to sensitive organisms.  The posed hypothesis that substantial amounts of androgenic substances are excreted via faeces of cows and sows was investigated through the course of this thesis. The suspected origin of those androgenic substances or their precursors is the placenta.  Faecal samples were taken at the day of oestrus and 16 days later from six cows and eight sows. Furthermore, faecal samples were taken from ten cows on day 150 and eight cows on day 240 of pregnancy. Faecal samples of eight sows were collected on day 110 of pregnancy. The samples were immediately frozen after collection, later extracted, and representative androstanes were measured using four enzyme immunoassays (aetiocholanolone, epiandrosterone, testosterone, and 5β-dihydrotestosterone enzyme immunoassays). Reversed-phase high performance liquid chromatography was used to characterize the immunoreactive substances. Using an androgen receptor assay, receptor active androgenic substances were measured.  In all samples immunoreactive and receptor-active androgens or their metabolites (all unconjugated) were detected. The concentration of all androstanes measured by the immunoassays and receptor active androgens increased towards the end of gestation, pointing towards a synthesis of them or their precursors in the placenta."}]},{"@type":"bf:Note","skos:prefLabel":[{"@language":"deu","@value":"Diplomarbeit - Veterinärmedizinische Universität Wien - 2026\n\nAus rechtlichen Gründen sind nicht alle Teile dieser Arbeit frei zugänglich. Der Zugriff auf den elektronischen Volltext ist auf Angehörige der Veterinärmedizinischen Universität Wien beschränkt. Bitte einloggen!"}]},{"@type":"bf:Summary","skos:prefLabel":[{"@language":"deu","@value":"Die physiologischen Auswirkungen, welche Androgene während der Trächtigkeit haben, sind noch nicht hinreichend erforscht, da Androgene in dieser Hinsicht oft nur als Vorstufe zur Bildung von Östrogenen betrachtet werden. Die enormen Mengen Kot, welche von Nutztieren ausgeschieden werden, könnten androgen wirksame Metaboliten enthalten, welche möglicherweise ein ökologisches Risiko für sensible Organismen darstellen.  Die Hypothese, welche im Rahmen dieser Diplomarbeit geprüft wurde, ist, dass nennenswerte Mengen an androgen aktiven Substanzen mit dem Kot von trächtigen Kühen und Säuen ausgeschieden werden. Der vermutete Ursprung dieser Substanzen oder ihrer Vorstufen ist dabei die Plazenta.  Kotproben von sechs Kühen und acht Säuen wurden am Tag des Östrus und 16 Tage danach entnommen. Am Tag 150 der Trächtigkeit wurden von zehn Kühen Kotproben entnommen, am Tag 240 der Trächtigkeit von acht Kühen. Am Tag 110 der Trächtigkeit wurden Kotproben von acht Säuen entnommen. Die Proben wurden umgehend tiefgefroren und später extrahiert. Die Konzentration repräsentativer Androstane wurde mittels vier Enzymimmunoassays (Ätiocholanolon, Epiandrosteron, Testosteron und 5β-Dihydrotestosteron Enzymimmunoassays) gemessen. Weiters wurden die immunreaktiven Substanzen mittels Reversed-Phase High Performance Liquid Chromatography charakterisiert. Mittels eines Androgenrezeptorassays wurden hormonaktive Substanzen gemessen.  In allen Proben waren immunreaktive und rezeptorbindende Androgene oder deren Metabolite (alle nicht konjugiert) vorhanden. Die Konzentration aller mittels Enzymimmunoassay gemessenen Substanzen aber auch der rezeptorbindenden Androgenen erhöhte sich gegen Ende der Trächtigkeit. Dies weist auf eine Bildung dieser oder ihrer Vorstufen in der Plazenta hin."}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Androstane im Kot von Nutztieren und ihre mögliche Bedeutung"}]}],"dcterms:issued":["2026"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"},{"@language":"ita","@value":"Documento PDF"}]}],"ebucore:filename":["vuwAC17926489.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/9E94-E3F8"],"skos:prefLabel":[{"@language":"eng","@value":"Diplomarbeit"},{"@language":"deu","@value":"Diplomarbeit"},{"@language":"ita","@value":"Tesi di diploma"}]}],"edm:rights":["http:\/\/rightsstatements.org\/vocab\/InC\/1.0\/"],"rdam:P30004":[{"@type":"phaidra:acnumber","@value":"AC17926489"},{"@type":"ids:doi","@value":"10.34876\/ef4y-g716"}],"rdax:P00009":[{"@type":"aiiso:Division","skos:exactMatch":["https:\/\/pid.phaidra.org\/vetmeduni-org\/E44T-Q4AC"],"skos:prefLabel":[{"@language":"deu","@value":"Zentrum für Biologische Wissenschaften"},{"@language":"eng","@value":"Centre of Biological Sciences"}]}],"role:assessor":[{"@type":"schema:Person","schema:familyName":[{"@value":"Verhovsek"}],"schema:givenName":[{"@value":"Doris"}]}],"role:aut":[{"@type":"schema:Person","schema:familyName":[{"@value":"Yaldez"}],"schema:givenName":[{"@value":"Franziska"}]}],"role:dgs":[{"@type":"schema:Person","schema:familyName":[{"@value":"Palme"}],"schema:givenName":[{"@value":"Rupert"}]}],"schema:numberOfPages":["37"]}