{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/spec\/#","frap":"http:\/\/purl.org\/cerif\/frapo","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"https:\/\/www.w3.org\/TR\/rdf-schema\/","relators":"http:\/\/id.loc.gov\/vocabulary\/relators","role":{"@context":{"aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"}}},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl","vra":"http:\/\/purl.org\/vra\/"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:5409","bf:note":[{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"Background\n\nHypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described.\n\nHypothesis\/Objectives\n\nTo describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST.\n\nAnimals\n\nTwenty-eight client-owned cats.\n\nMethods\n\nMulti-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1] ± clinical signs compatible with acromegaly ± documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed.\n\nResults\n\nTwenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5 years (±SD 3.5 years); mean body weight was 7.1 kg (±SD 2.1 kg). The median serum IGF-1 concentration was 1236 ng\/mL (range 704-2455 ng\/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13\/28), weight gain (12\/28), broad facial features (10\/28), abdominal enlargement (10\/28), respiratory stridor (9\/28), polyphagia (9\/28), and signs of neurological disease (3\/28). The most common clinicopathological abnormalities were hyperproteinemia (12\/28), serum creatinine above the reference interval (RI) (10\/28), and urinary specific gravity below the RI (9\/28). Hypertrophic cardiomyopathy phenotype was identified in 8\/17 cases. The most common comorbidity was chronic kidney disease (10\/28). The median survival time after diagnosis was 24 months (range 1-103 months).\n\nConclusions and clinical importance\n\nHypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor."}]}],"bf:provisionActivity":[{"@type":"bf:Publication","bf:agent":[{"@type":"schema:Organization","schema:name":[{"@value":"Oxford University Press"}]}]}],"dce:rights":[{"@language":"eng","@value":"© The Author(s) 2026"}],"dce:subject":[{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Acromegaly"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Cats"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"GH Excess"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Nondiabetic"}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)"}]}],"dcterms:accessRights":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/QW5R-NG4J"],"skos:prefLabel":[{"@language":"eng","@value":"open access"},{"@language":"ita","@value":"Open Access"}]}],"dcterms:issued":["2026"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"},{"@language":"ita","@value":"Documento PDF"}]}],"ebucore:filename":["aalaf050.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/VKA6-9XTY"],"skos:prefLabel":[{"@language":"eng","@value":"journal article"},{"@language":"deu","@value":"Wissenschaftlicher Artikel"},{"@language":"ita","@value":"Articolo scientifico"}]}],"edm:rights":["http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"],"oaire:version":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/PMR8-3C8D"],"skos:prefLabel":[{"@language":"eng","@value":"version of record (published version)"},{"@language":"ita","@value":"Versione editoriale\/Version of Record"}]}],"rdam:P30004":[{"@type":"ids:doi","@value":"10.1093\/jvimsj\/aalaf050"}],"rdau:P60193":[{"@type":"schema:CreativeWork","bibo:issue":[{"@value":"1"}],"bibo:volume":[{"@value":"40"}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Journal of Veterinary Internal Medicine"}]}],"dcterms:issued":["2026"],"ids:issn":["1939-1676"]}],"rdax:P00009":[{"@type":"aiiso:Division","skos:exactMatch":["https:\/\/pid.phaidra.org\/vetmeduni-org\/4PCV-349B"],"skos:prefLabel":[{"@language":"deu","@value":"Klinisches Zentrum für Kleintiere"},{"@language":"eng","@value":"Clinical Centre for Small Animal Health and Research"}]}],"role:aut":[{"@type":"schema:Person","schema:familyName":[{"@value":"Miceli"}],"schema:givenName":[{"@value":"Diego"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Niessen"}],"schema:givenName":[{"@value":"Stijn J M"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Rey Amunategui"}],"schema:givenName":[{"@value":"Juan P"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@language":"deu","@value":"Klinisches Zentrum für Kleintiere"},{"@language":"eng","@value":"Clinical Centre for Small Animal Health and Research"}],"skos:exactMatch":["https:\/\/pid.phaidra.org\/vetmeduni-org\/4PCV-349B"]}],"schema:familyName":[{"@value":"Zeugswetter"}],"schema:givenName":[{"@value":"Florian K"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0001-5944-0375"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Pompili"}],"schema:givenName":[{"@value":"Gustavo"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Tavares"}],"schema:givenName":[{"@value":"Flavia"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Molina"}],"schema:givenName":[{"@value":"Estela"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Leal"}],"schema:givenName":[{"@value":"Rodolfo"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Espiñeira"}],"schema:givenName":[{"@value":"Ignacio"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Bota"}],"schema:givenName":[{"@value":"Doroteia"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Corsini"}],"schema:givenName":[{"@value":"Andrea"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Fracassi"}],"schema:givenName":[{"@value":"Federico"}]}],"schema:numberOfPages":["9"]}