
<resource xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:datacite="http://datacite.org/schema/kernel-4" xmlns="http://namespace.openaire.eu/schema/oaire/" xsi:schemaLocation="http://namespace.openaire.eu/schema/oaire/ https://www.openaire.eu/schema/repo-lit/4.0/openaire.xsd">
  
<datacite:identifier identifierType="URL">https://phaidra.vetmeduni.ac.at/o:5375</datacite:identifier>

  
<datacite:titles>
  
<datacite:title xml:lang="en">A new principle to attenuate ischemia-reperfusion injury in kidney transplantation</datacite:title>

  
</datacite:titles>

  
<datacite:creators>
  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Biglarnia, Ali-Reza</datacite:creatorName>

  
<datacite:givenName>Ali-Reza</datacite:givenName>

  
<datacite:familyName>Biglarnia</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0009-0004-2293-0740</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Teramura, Yuji</datacite:creatorName>

  
<datacite:givenName>Yuji</datacite:givenName>

  
<datacite:familyName>Teramura</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-0709-1000</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Asif, Sana</datacite:creatorName>

  
<datacite:givenName>Sana</datacite:givenName>

  
<datacite:familyName>Asif</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-7924-0936</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Dührkop, Claudia</datacite:creatorName>

  
<datacite:givenName>Claudia</datacite:givenName>

  
<datacite:familyName>Dührkop</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0009-0006-9405-4035</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Manivel, Vivek Anand</datacite:creatorName>

  
<datacite:givenName>Vivek Anand</datacite:givenName>

  
<datacite:familyName>Manivel</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-6746-7372</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Manell, Elin</datacite:creatorName>

  
<datacite:givenName>Elin</datacite:givenName>

  
<datacite:familyName>Manell</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-4491-7609</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Hedenqvist, Patricia</datacite:creatorName>

  
<datacite:givenName>Patricia</datacite:givenName>

  
<datacite:familyName>Hedenqvist</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-4540-6250</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Rydén, Anneli</datacite:creatorName>

  
<datacite:givenName>Anneli</datacite:givenName>

  
<datacite:familyName>Rydén</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-3070-5023</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Sellberg, Felix</datacite:creatorName>

  
<datacite:givenName>Felix</datacite:givenName>

  
<datacite:familyName>Sellberg</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-9742-244X</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Fromell, Karin</datacite:creatorName>

  
<datacite:givenName>Karin</datacite:givenName>

  
<datacite:familyName>Fromell</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-8905-8791</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Hammer, Sabine</datacite:creatorName>

  
<datacite:givenName>Sabine</datacite:givenName>

  
<datacite:familyName>Hammer</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-1475-3938</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Huber-Lang, Markus</datacite:creatorName>

  
<datacite:givenName>Markus</datacite:givenName>

  
<datacite:familyName>Huber-Lang</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-2359-6516</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Ekdahl, Kristina N.</datacite:creatorName>

  
<datacite:givenName>Kristina N.</datacite:givenName>

  
<datacite:familyName>Ekdahl</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-7888-1571</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Jensen-Waern, Marianne</datacite:creatorName>

  
<datacite:givenName>Marianne</datacite:givenName>

  
<datacite:familyName>Jensen-Waern</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-6195-7066</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Nilsson, Bo</datacite:creatorName>

  
<datacite:givenName>Bo</datacite:givenName>

  
<datacite:familyName>Nilsson</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-0057-2730</datacite:nameIdentifier>

  
</datacite:creator>

  
</datacite:creators>

  
<dc:publisher>Elsevier</dc:publisher>

  
<resourceType resourceTypeGeneral="literature" uri="http://purl.org/coar/resource_type/c_6501">journal article</resourceType>

  
<datacite:rights rightsURI="http://purl.org/coar/access_right/c_abf2">open access</datacite:rights>

  
<dc:language>eng</dc:language>

  
<dc:description xml:lang="en">Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective cell membrane barrier, preventing the recognition of ligands exposed on renal cells by plasma proteins and cells of the intravascular innate immune system. In vitro cell studies confirmed the safety of PEG-LIPID with no observed toxicity and demonstrated its efficacy in masking ligands on various cell types. The PEG-LIPID was evaluated in 3 porcine allogeneic transplant models: 1 acute dual en bloc nonsurvival transplant model (duration 6 hours) and 2 survival models with low and high ischemic stress, respectively (duration 96 hours). No immunosuppression was employed. Across all 3 porcine transplant models, PEG-LIPID consistently mitigated ischemia-reperfusion-induced thromboinflammation (complement, coagulation, and kallikrein/kinin activation) and long-term inflammation with a marked reduction in cytokine responses, including lower levels of interleukin 6. The PEG-LIPID-treated kidneys exhibited significantly improved allograft function, reflected in robustly lower creatinine levels. This translational study confirmed that the PIG-LIPID is a strong candidate drug to mitigate ischemia-reperfusion injury in clinical kidney transplantation.</dc:description>

  
<datacite:subjects>
  
<datacite:subject xml:lang="en">Intravascular Innate Immunity</datacite:subject>

  
<datacite:subject xml:lang="en">Ischemia-reperfusion Injury</datacite:subject>

  
<datacite:subject xml:lang="en">Kidney Transplantation</datacite:subject>

  
<datacite:subject xml:lang="en">Pretreatment Modality</datacite:subject>

  
</datacite:subjects>

  
<licenseCondition uri="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</licenseCondition>

  
<file accessRightsURI="http://purl.org/coar/access_right/c_abf2" mimeType="application/pdf" objectType="fulltext">https://phaidra.vetmeduni.ac.at/api/object/o:5375/download</file>

  
<datacite:alternateIdentifiers>
  
<datacite:alternateIdentifier alternateIdentifierType="DOI">10.1016/j.ajt.2025.08.024</datacite:alternateIdentifier>

  
</datacite:alternateIdentifiers>

  
<datacite:relatedIdentifiers>
  
<datacite:relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://phaidra.vetmeduni.ac.at/o:605</datacite:relatedIdentifier>

  
</datacite:relatedIdentifiers>

  
<dc:format>application/pdf</dc:format>

  
<dc:source xml:lang="en">American Journal of Transplantation</dc:source>

  
<dc:source>issn:1600-6135</dc:source>

  
<version uri="http://purl.org/coar/version/c_970fb48d4fbd8a85">VoR</version>

  
<citationTitle>American Journal of Transplantation</citationTitle>

  
<citationVolume>26</citationVolume>

  
<citationIssue>2</citationIssue>

  
<datacite:sizes>
  
<datacite:size>4.73 MB</datacite:size>

  
</datacite:sizes>

  
<datacite:dates>
  
<datacite:date dateType="Issued">2026</datacite:date>

  
</datacite:dates>

  
</resource>