{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/spec\/#","frap":"http:\/\/purl.org\/cerif\/frapo","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"https:\/\/www.w3.org\/TR\/rdf-schema\/","relators":"http:\/\/id.loc.gov\/vocabulary\/relators","role":{"@context":{"aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"}}},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:5361","bf:note":[{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"Background\/Objectives: Radiolabeled fibroblast activation protein inhibitors (FAPIs) are emerging as promising imaging agents assessing fibrotic diseases. This study evaluates [68Ga]Ga-DATA5m.SA.FAPi for imaging pulmonary fibrosis in two mouse models, bleomycin-induced (BLM) and a transgenic (fra-2tg) model, both displaying characteristics of human pulmonary fibrotic diseases. Methods: In the BLM model, C57BL\/6 mice were treated with bleomycin or isotonic sodium chloride (controls) for 4, 5, and 6 weeks, followed by [68Ga]Ga-DATA5m.SA.FAPi PET\/CT scans. Fra-2tg mice and wildtype (WT) littermates underwent at 7, 11, and 18\/19 weeks of age a PET\/CT scan. The selected timepoints correspond to early, middle, and late disease stages for each model. Imaging was complemented by ex vivo quantification, histological, and immunohistochemical (IHC) analyses. Results: In BLM mice, pulmonary [68Ga]Ga-DATA5m.SA.FAPi uptake showed a trend toward increase as early as 5 weeks of treatment compared with the controls, which was confirmed by ex vivo analysis (BLM: 3.31 ± 0.29%ID\/g, n = 5; control: 1.61 ± 0.29%ID\/g, n = 4; p = 0.0035). In fra-2tg mice, no significant differences could be detected. IHC revealed elevated pulmonary FAP expression specifically at early (BLM) and mild (fra-2tg) disease stages, whereas for BLM, tracer uptake was more pronounced at later stages. Conclusions: Our findings complement and extend observations from previous studies and support the potential of FAPI tracers as molecular imaging agents for pulmonary fibrosis."}]}],"bf:provisionActivity":[{"@type":"bf:Publication","bf:agent":[{"@type":"schema:Organization","schema:name":[{"@value":"MDPI"}]}]}],"dce:rights":[{"@language":"eng","@value":"© 2025 by the authors"}],"dce:subject":[{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"FAP"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Fibrosis"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"PET"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Bleomycin"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Fra-2"}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"FAPI Tracer en Vogue: Evaluating [68Ga]Ga-DATA5m.SA.FAPi for Molecular Imaging of Pulmonary Fibrosis"}]}],"dcterms:accessRights":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/QW5R-NG4J"],"skos:prefLabel":[{"@language":"eng","@value":"open access"},{"@language":"ita","@value":"Open Access"}]}],"dcterms:issued":["2026"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"},{"@language":"ita","@value":"Documento PDF"}]}],"ebucore:filename":["pharmaceuticals-19-00034.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/VKA6-9XTY"],"skos:prefLabel":[{"@language":"eng","@value":"journal article"},{"@language":"deu","@value":"Wissenschaftlicher Artikel"},{"@language":"ita","@value":"Articolo scientifico"}]}],"edm:rights":["http:\/\/creativecommons.org\/licenses\/by\/4.0\/"],"oaire:version":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/PMR8-3C8D"],"skos:prefLabel":[{"@language":"eng","@value":"version of record (published version)"},{"@language":"ita","@value":"Versione editoriale\/Version of Record"}]}],"rdam:P30004":[{"@type":"ids:doi","@value":"10.3390\/ph19010034"}],"rdau:P60193":[{"@type":"schema:CreativeWork","bibo:issue":[{"@value":"1"}],"bibo:volume":[{"@value":"19"}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Pharmaceuticals"}]}],"dcterms:issued":["2026"],"ids:issn":["1424-8247"]}],"role:aut":[{"@type":"schema:Person","schema:familyName":[{"@value":"Weissenböck"}],"schema:givenName":[{"@value":"Victoria"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Schlederer"}],"schema:givenName":[{"@value":"Michaela"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Bakiri"}],"schema:givenName":[{"@value":"Latifa"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-6300-2420"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Schaffenrath"}],"schema:givenName":[{"@value":"Johanna"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0003-1689-1648"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Wagner"}],"schema:givenName":[{"@value":"Erwin F."}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Rösch"}],"schema:givenName":[{"@value":"Frank"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Hacker"}],"schema:givenName":[{"@value":"Marcus"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-4222-4083"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Kenner"}],"schema:givenName":[{"@value":"Lukas"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0003-2184-1338"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Philippe"}],"schema:givenName":[{"@value":"Cécile"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-7203-7174"}]}],"schema:numberOfPages":["16"]}