
<resource xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:datacite="http://datacite.org/schema/kernel-4" xmlns="http://namespace.openaire.eu/schema/oaire/" xsi:schemaLocation="http://namespace.openaire.eu/schema/oaire/ https://www.openaire.eu/schema/repo-lit/4.0/openaire.xsd">
  
<datacite:identifier identifierType="URL">https://phaidra.vetmeduni.ac.at/o:5279</datacite:identifier>

  
<datacite:titles>
  
<datacite:title xml:lang="en">STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts</datacite:title>

  
</datacite:titles>

  
<datacite:creators>
  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Dennaoui, Rayane</datacite:creatorName>

  
<datacite:givenName>Rayane</datacite:givenName>

  
<datacite:familyName>Dennaoui</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Wicker, Madison N.</datacite:creatorName>

  
<datacite:givenName>Madison N.</datacite:givenName>

  
<datacite:familyName>Wicker</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Moen, Carson</datacite:creatorName>

  
<datacite:givenName>Carson</datacite:givenName>

  
<datacite:familyName>Moen</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Schlederer, Michaela</datacite:creatorName>

  
<datacite:givenName>Michaela</datacite:givenName>

  
<datacite:familyName>Schlederer</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Vistisen, Kerry</datacite:creatorName>

  
<datacite:givenName>Kerry</datacite:givenName>

  
<datacite:familyName>Vistisen</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Triplett, Aleata A.</datacite:creatorName>

  
<datacite:givenName>Aleata A.</datacite:givenName>

  
<datacite:familyName>Triplett</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Rülicke, Thomas</datacite:creatorName>

  
<datacite:givenName>Thomas</datacite:givenName>

  
<datacite:familyName>Rülicke</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-2121-9496</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Rui, Hallgeir</datacite:creatorName>

  
<datacite:givenName>Hallgeir</datacite:givenName>

  
<datacite:familyName>Rui</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Kenner, Lukas</datacite:creatorName>

  
<datacite:givenName>Lukas</datacite:givenName>

  
<datacite:familyName>Kenner</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-2184-1338</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Casanova, Emilio</datacite:creatorName>

  
<datacite:givenName>Emilio</datacite:givenName>

  
<datacite:familyName>Casanova</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Wagner, Kay-Uwe</datacite:creatorName>

  
<datacite:givenName>Kay-Uwe</datacite:givenName>

  
<datacite:familyName>Wagner</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-5081-0226</datacite:nameIdentifier>

  
</datacite:creator>

  
</datacite:creators>

  
<dc:publisher>Elsevier</dc:publisher>

  
<resourceType resourceTypeGeneral="literature" uri="http://purl.org/coar/resource_type/c_6501">journal article</resourceType>

  
<datacite:rights rightsURI="http://purl.org/coar/access_right/c_abf2">open access</datacite:rights>

  
<dc:language>eng</dc:language>

  
<dc:description xml:lang="en">Janus kinases 1 and 2 and STAT transcription factors are critical signaling nodes for numerous growth factors. In the mammary gland, JAK2 and STAT5a/b are essential for alveolar cell differentiation and lactation, but little is known about the cooperative roles of JAKs and STATs before pregnancy. We examined female mice conditionally deficient in JAK1/2 and discovered that both kinases jointly regulate epithelial cell proliferation and ductal morphogenesis. To assess the role of downstream STATs, we generated genetic models co-deficient in STAT3/5a/5b with or without STAT1 or JAK1. Although loss of STAT3/5a/5b leads to a JAK1-dependent upregulation of STAT1, the formation of mammary ducts is unaffected by the lack of expression and activation of all seven STAT proteins. Additionally, STAT deficiency impairs the cytokine-induced autophosphorylation of JAK1/2. These findings suggest that mammary duct development is orchestrated by STAT-independent signaling mechanisms of JAK1 and JAK2, potentially beyond their roles as tyrosine kinases.</dc:description>

  
<datacite:subjects>
  
<datacite:subject xml:lang="en">Signal Transduction</datacite:subject>

  
<datacite:subject xml:lang="en">Janus Tyrosine Kinases</datacite:subject>

  
<datacite:subject xml:lang="en">KAK1</datacite:subject>

  
<datacite:subject xml:lang="en">JAK2</datacite:subject>

  
<datacite:subject xml:lang="en">STAT Proteins</datacite:subject>

  
<datacite:subject xml:lang="en">Gene Targeting</datacite:subject>

  
<datacite:subject xml:lang="en">Conditional Knockout</datacite:subject>

  
<datacite:subject xml:lang="en">Mammary Gland Developement</datacite:subject>

  
<datacite:subject xml:lang="en">Protein-tyrosine Kinase</datacite:subject>

  
<datacite:subject xml:lang="en">Morphogenesis</datacite:subject>

  
<datacite:subject xml:lang="en">Growth And Development</datacite:subject>

  
<datacite:subject xml:lang="en">Female</datacite:subject>

  
<datacite:subject xml:lang="en">DNA-binding Proteins</datacite:subject>

  
<datacite:subject xml:lang="en">Cre Recombinase</datacite:subject>

  
</datacite:subjects>

  
<licenseCondition uri="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</licenseCondition>

  
<file accessRightsURI="http://purl.org/coar/access_right/c_abf2" mimeType="application/pdf" objectType="fulltext">https://phaidra.vetmeduni.ac.at/api/object/o:5279/download</file>

  
<datacite:alternateIdentifiers>
  
<datacite:alternateIdentifier alternateIdentifierType="DOI">10.1016/j.celrep.2025.116703</datacite:alternateIdentifier>

  
</datacite:alternateIdentifiers>

  
<datacite:relatedIdentifiers>
  
<datacite:relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://phaidra.vetmeduni.ac.at/o:605</datacite:relatedIdentifier>

  
</datacite:relatedIdentifiers>

  
<dc:format>application/pdf</dc:format>

  
<dc:source xml:lang="en">Cell Reports</dc:source>

  
<dc:source>issn:2211-1247</dc:source>

  
<version uri="http://purl.org/coar/version/c_970fb48d4fbd8a85">VoR</version>

  
<citationTitle>Cell Reports</citationTitle>

  
<citationVolume>45</citationVolume>

  
<citationIssue>1</citationIssue>

  
<datacite:sizes>
  
<datacite:size>14.72 MB</datacite:size>

  
</datacite:sizes>

  
<datacite:dates>
  
<datacite:date dateType="Issued">2026</datacite:date>

  
</datacite:dates>

  
</resource>