https://phaidra.vetmeduni.ac.at/o:5216 A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution Ehlich, Hilke Hilke Ehlich 0000-0002-9355-4832 Blease, Andrew Andrew Blease 0000-0001-5784-7016 Biju, Reva Reva Biju 0009-0000-0598-6436 Gustems, Montse Montse Gustems 0000-0003-4447-0031 Song, Fei Fei Song 0009-0007-2626-7925 Fessele, Sabine Sabine Fessele 0000-0002-5399-3574 Massimi, Marzia Marzia Massimi 0000-0001-5052-1822 Bozonelos, Konstantinos Konstantinos Bozonelos Ntafis, Vasileios Vasileios Ntafis 0000-0003-1271-1187 Hiltunen, Anniina E. Anniina E. Hiltunen 0000-0003-4019-6960 Marschall, Susan Susan Marschall 0000-0001-5191-7060 Stoeger, Claudia Claudia Stoeger 0000-0001-8361-0274 Khorshidi, Zuzana Zuzana Khorshidi Ziadi, Abdelmalek Abdelmalek Ziadi 0009-0005-5430-2121 Jambou, Karine Karine Jambou 0009-0007-6256-2446 Armagno, Arsenio Arsenio Armagno 0009-0001-5965-8646 Scavizzi, Ferdinando Ferdinando Scavizzi 0000-0002-4483-6753 Raspa, Marcello Marcello Raspa 0000-0002-3437-2430 Fernandez, Julia Julia Fernandez del Hierro, María Jesús María Jesús del Hierro 0000-0001-8883-0671 Ayadi, Abdelkader Abdelkader Ayadi 0000-0002-7446-9659 Pensavalle, Joelle Joelle Pensavalle Prevost, Géraldine Géraldine Prevost Dufková, Lucie Lucie Dufková 0009-0006-7674-426X Krupkova, Michaela Michaela Krupkova 0000-0002-9371-2511 Nickl, Petr Petr Nickl 0000-0002-4289-0502 Krimpenfort, Paul Paul Krimpenfort van de Ven, Marieke Marieke van de Ven 0000-0001-6779-9353 Jonkers, Jos Jos Jonkers 0000-0002-9264-9792 Valera Vázquez, Gema Gema Valera Vázquez 0000-0001-5411-7560 Raess, Michael Michael Raess 0000-0002-8759-1186 Beckers, Johannes Johannes Beckers 0000-0001-7874-3822 Moles, Anna Anna Moles 0000-0002-5805-5763 Dahlhoff, Maik Maik Dahlhoff 0000-0001-9189-7631 University of Veterinary Medicine Vienna Montoliu, Lluis Lluis Montoliu 0000-0003-3941-1176 Hérault, Yann Yann Hérault 0000-0001-7049-6900 Hinttala, Reetta Reetta Hinttala 0000-0002-7642-4008 Kontoyiannis, Dimitris L. Dimitris L. Kontoyiannis 0000-0003-4682-9490 Sedlacek, Radislav Radislav Sedlacek 0000-0002-3352-392X Hrabě de Angelis, Martin Martin Hrabě de Angelis 0000-0002-7898-2353 Boersma, Auke A. Auke A. Boersma 0000-0002-3066-2836 University of Veterinary Medicine Vienna Matteoni, Rafaele Rafaele Matteoni 0000-0002-0314-5948 Springer journal article open access eng Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastructure, plays a key role in this effort by cryopreserving scientifically validated mutant mouse and rat strains and making them accessible to the global scientific community. To further enhance its processes and promote transparency, INFRAFRONTIER/EMMA has developed a set of ten Quality Principles specifically tailored to the unique requirements of cryopreserved rodent mutant strains. These principles guide EMMA’s workflows by providing a structured yet flexible quality framework across its distributed nodes. They encompass both general standards—such as adherence to the 3Rs (Replace, Reduce, Refine), staff competence, and continuous improvement—and more specific areas including scientific evaluation, data curation, and intellectual property rights. Each principle is presented with contextual background, defined requirements, practical recommendations, and key references. This initiative aims to strengthen the reliability, ethical integrity, and reproducibility of preclinical research resources. http://creativecommons.org/licenses/by-nc-nd/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:5216/download 10.1007/s00335-025-10174-4 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Mammalian Genome issn:0938-8990 VoR Mammalian Genome 37 1.52 MB 2026