© 2025, The Author(s) open access Springer eng Open Access Text journal article application/pdf Mammalian Genome A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution Hilke Ehlich Andrew Blease Reva Biju Montse Gustems Fei Song Sabine Fessele Marzia Massimi Konstantinos Bozonelos Vasileios Ntafis Anniina E. Hiltunen Susan Marschall Claudia Stoeger Zuzana Khorshidi Abdelmalek Ziadi Karine Jambou Arsenio Armagno Ferdinando Scavizzi Marcello Raspa Julia Fernandez María Jesús del Hierro Abdelkader Ayadi Joelle Pensavalle Géraldine Prevost Lucie Dufková Michaela Krupkova Petr Nickl Paul Krimpenfort Marieke van de Ven Jos Jonkers Gema Valera Vázquez Michael Raess Johannes Beckers Anna Moles Maik Dahlhoff Lluis Montoliu Yann Hérault Reetta Hinttala Dimitris L. Kontoyiannis Radislav Sedlacek Martin Hrabě de Angelis Auke A. Boersma Rafaele Matteoni Text Wissenschaftlicher Artikel doi:10.1007/s00335-025-10174-4 http://creativecommons.org/licenses/by-nc-nd/4.0/ Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastructure, plays a key role in this effort by cryopreserving scientifically validated mutant mouse and rat strains and making them accessible to the global scientific community. To further enhance its processes and promote transparency, INFRAFRONTIER/EMMA has developed a set of ten Quality Principles specifically tailored to the unique requirements of cryopreserved rodent mutant strains. These principles guide EMMA’s workflows by providing a structured yet flexible quality framework across its distributed nodes. They encompass both general standards—such as adherence to the 3Rs (Replace, Reduce, Refine), staff competence, and continuous improvement—and more specific areas including scientific evaluation, data curation, and intellectual property rights. Each principle is presented with contextual background, defined requirements, practical recommendations, and key references. This initiative aims to strengthen the reliability, ethical integrity, and reproducibility of preclinical research resources. Documento PDF Articolo scientifico 2026 https://phaidra.vetmeduni.ac.at/o:5216