Hilke Ehlich Hilke Ehlich Andrew Blease Andrew Blease Reva Biju Reva Biju Montse Gustems Montse Gustems Fei Song Fei Song Sabine Fessele Sabine Fessele Marzia Massimi Marzia Massimi Konstantinos Bozonelos Konstantinos Bozonelos Vasileios Ntafis Vasileios Ntafis Anniina E. Hiltunen Anniina E. Hiltunen Susan Marschall Susan Marschall Claudia Stoeger Claudia Stoeger Zuzana Khorshidi Zuzana Khorshidi Abdelmalek Ziadi Abdelmalek Ziadi Karine Jambou Karine Jambou Arsenio Armagno Arsenio Armagno Ferdinando Scavizzi Ferdinando Scavizzi Marcello Raspa Marcello Raspa Julia Fernandez Julia Fernandez María Jesús del Hierro María Jesús del Hierro Abdelkader Ayadi Abdelkader Ayadi Joelle Pensavalle Joelle Pensavalle Géraldine Prevost Géraldine Prevost Lucie Dufková Lucie Dufková Michaela Krupkova Michaela Krupkova Petr Nickl Petr Nickl Paul Krimpenfort Paul Krimpenfort Marieke van de Ven Marieke van de Ven Jos Jonkers Jos Jonkers Gema Valera Vázquez Gema Valera Vázquez Michael Raess Michael Raess Johannes Beckers Johannes Beckers Anna Moles Anna Moles Maik Dahlhoff Maik Dahlhoff Lluis Montoliu Lluis Montoliu Yann Hérault Yann Hérault Reetta Hinttala Reetta Hinttala Dimitris L. Kontoyiannis Dimitris L. Kontoyiannis Radislav Sedlacek Radislav Sedlacek Martin Hrabě de Angelis Martin Hrabě de Angelis Auke A. Boersma Auke A. Boersma Rafaele Matteoni Rafaele Matteoni Springer 2026 Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastructure, plays a key role in this effort by cryopreserving scientifically validated mutant mouse and rat strains and making them accessible to the global scientific community. To further enhance its processes and promote transparency, INFRAFRONTIER/EMMA has developed a set of ten Quality Principles specifically tailored to the unique requirements of cryopreserved rodent mutant strains. These principles guide EMMA’s workflows by providing a structured yet flexible quality framework across its distributed nodes. They encompass both general standards—such as adherence to the 3Rs (Replace, Reduce, Refine), staff competence, and continuous improvement—and more specific areas including scientific evaluation, data curation, and intellectual property rights. Each principle is presented with contextual background, defined requirements, practical recommendations, and key references. This initiative aims to strengthen the reliability, ethical integrity, and reproducibility of preclinical research resources. PDFDocument eng 2026-06-25T14:25:28.190785627Z 2026 1597607 b application/pdf http://creativecommons.org/licenses/by-nc-nd/4.0/