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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1371/journal.ppat.1013553</lom:langstring>

  
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</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins</lom:langstring>

  
</lom:title>

  
<lom:description>
  
<lom:langstring xml:lang="en">High-resolution structural studies have mainly focused on two out of the six adenovirus genera: mastadenoviruses and atadenoviruses. Here we report the high-resolution structure of an aviadenovirus, the poultry pathogen fowl adenovirus serotype 4 (FAdV-C4). FAdV-C4 virions are highly thermostable, despite lacking minor coat and core proteins shown to stabilize the mast- and atadenovirus particles, having no genus-specific cementing proteins, and packaging a 25% longer genome. Unique structural features of the FAdV-C4 hexon include a large insertion at the trimer equatorial region, and a long N-terminal tail. Protein IIIa conformation is closer to atadenoviruses than to mastadenoviruses, while protein VIII diverges from all previously reported structures. We interpret these differences in light of adenovirus evolution. Finally, we discuss the possible role of core composition in determining capsid stability properties. These results enlarge our view on the structural diversity of adenoviruses, and provide useful information to counteract fowl pathogens or use non-human adenoviruses as vectors.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
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<lom:langstring xml:lang="en">Viral Structure</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Protein Interactions</lom:langstring>

  
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<lom:keyword>
  
<lom:langstring xml:lang="en">Monomers</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Bird Genomics</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Protein Structure</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Virions</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Adenoviruses</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Viral Packaging</lom:langstring>

  
</lom:keyword>

  
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<lom:datetime>2026-04-28T09:00:58.827Z</lom:datetime>

  
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<lom:vcard>BEGIN:VCARD
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N:Pérez-Illana;Marta;
FN:Marta Pérez-Illana
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N:Schachner;Anna;
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<lom:vcard>BEGIN:VCARD
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N:Hernando-Pérez;Mercedes;
FN:Mercedes Hernando-Pérez
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<lom:vcard>BEGIN:VCARD
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N:Condezo;Gabriela N.;
FN:Gabriela N. Condezo
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Paradela;Alberto;
FN:Alberto Paradela
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Martínez;Marta;
FN:Marta Martínez
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Marabini;Roberto;
FN:Roberto Marabini
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<lom:vcard>BEGIN:VCARD
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N:Hess;Michael;
FN:Michael Hess
X-ORCID:https://orcid.org/0000-0002-6991-0120
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:San Martín;Carmen;
FN:Carmen San Martín
X-ORCID:https://orcid.org/0000-0001-9799-175X
END:VCARD</lom:vcard>

  
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