phaidra.vetmeduni.ac.at o:5065 DOI 10.3390/ani15223238 Bioavailability of Thymol Incorporated into Gastro-Resistant Self-Emulsifying Pellets in Rabbits Thymol gastro-resistant self-emulsifying pellets were used to achieve thymol targeted release on the side of the intestine with the most intensive absorption to enhance its oral bioavailability. Forty-eight rabbits (35 d of age) were divided into two groups fed with a standard diet containing gastro-resistant enteric pellets (control, CG; without thymol, initial live weight 1350.0 ± 18.0, and experimental, EG; with thymol 250 mg/kg, initial live weight 1352.0 ± 19.9 g). The experiment lasted 28 days: thymol was administered for 21 days and then withdrawn for 7 days. Thymol was significantly higher in duodenal wall (DW) than in plasma during both periods (p = 0.0053, p < 0.0001). Significant correlation was established between thymol concentration in plasma and DW during its application (rs = 0.9333, p < 0.001). Thymol was below the limit of quantitation in plasma, spleen and muscle only after its withdrawal, and its significantly higher concentration in kidney and fat than in plasma (p = 0.0182, p = 0.0003) and muscle (p = 0.0236, p = 0.0004) indicates its efficient accumulation. Thymol in gastro-resistant form prevented its degradation due to adverse conditions in the stomach and ensured its release at the site of greatest absorption in the small intestine. eng Thymol Self-emulsifying Pellets Oral Bioavailability Rabbits Metabolism 2026-04-23T08:33:07.729Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Kristofova;Radoslava; FN:Radoslava Kristofova X-ORCID:https://orcid.org/0000-0002-5169-2858 END:VCARD BEGIN:VCARD VERSION:3.0 N:Zitterl-Eglseer;Karin; FN:Karin Zitterl-Eglseer X-ORCID:https://orcid.org/0000-0002-6908-7074 END:VCARD BEGIN:VCARD VERSION:3.0 N:Firooznia;Fardad; FN:Fardad Firooznia END:VCARD BEGIN:VCARD VERSION:3.0 N:Laukova;Andrea; FN:Andrea Laukova X-ORCID:https://orcid.org/0000-0001-7413-3816 END:VCARD BEGIN:VCARD VERSION:3.0 N:Chrastinova;Lubica; FN:Lubica Chrastinova END:VCARD BEGIN:VCARD VERSION:3.0 N:Pogany Simonova;Monika; FN:Monika Pogany Simonova X-ORCID:https://orcid.org/0000-0002-0377-4672 END:VCARD BEGIN:VCARD VERSION:3.0 N:Takacsova;Margareta; FN:Margareta Takacsova X-ORCID:https://orcid.org/0000-0002-7478-9177 END:VCARD BEGIN:VCARD VERSION:3.0 N:Bacova;Kristina; FN:Kristina Bacova X-ORCID:https://orcid.org/0000-0002-1856-4475 END:VCARD BEGIN:VCARD VERSION:3.0 N:Placha;Iveta; FN:Iveta Placha X-ORCID:https://orcid.org/0000-0002-8724-0159 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 934903 https://phaidra.vetmeduni.ac.at/o:5065 https://phaidra.vetmeduni.ac.at/api/object/o:5065/thumbnail LOMv1.0 discipline