{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/spec\/#","frap":"http:\/\/purl.org\/cerif\/frapo","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"https:\/\/www.w3.org\/TR\/rdf-schema\/","relators":"http:\/\/id.loc.gov\/vocabulary\/relators","role":{"@context":{"aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"}}},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:5065","bf:note":[{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"Thymol gastro-resistant self-emulsifying pellets were used to achieve thymol targeted release on the side of the intestine with the most intensive absorption to enhance its oral bioavailability. Forty-eight rabbits (35 d of age) were divided into two groups fed with a standard diet containing gastro-resistant enteric pellets (control, CG; without thymol, initial live weight 1350.0 ± 18.0, and experimental, EG; with thymol 250 mg\/kg, initial live weight 1352.0 ± 19.9 g). The experiment lasted 28 days: thymol was administered for 21 days and then withdrawn for 7 days. Thymol was significantly higher in duodenal wall (DW) than in plasma during both periods (p = 0.0053, p < 0.0001). Significant correlation was established between thymol concentration in plasma and DW during its application (rs = 0.9333, p < 0.001). Thymol was below the limit of quantitation in plasma, spleen and muscle only after its withdrawal, and its significantly higher concentration in kidney and fat than in plasma (p = 0.0182, p = 0.0003) and muscle (p = 0.0236, p = 0.0004) indicates its efficient accumulation. Thymol in gastro-resistant form prevented its degradation due to adverse conditions in the stomach and ensured its release at the site of greatest absorption in the small intestine."}]}],"bf:provisionActivity":[{"@type":"bf:Publication","bf:agent":[{"@type":"schema:Organization","schema:name":[{"@value":"MDPI"}]}]}],"dce:rights":[{"@language":"eng","@value":"© 2025 by the authors."}],"dce:subject":[{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Thymol"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Self-emulsifying Pellets"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Oral Bioavailability"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Rabbits"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Metabolism"}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Bioavailability of Thymol Incorporated into Gastro-Resistant Self-Emulsifying Pellets in Rabbits"}]}],"dcterms:accessRights":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/QW5R-NG4J"],"skos:prefLabel":[{"@language":"eng","@value":"open access"},{"@language":"ita","@value":"Open Access"}]}],"dcterms:issued":["2025"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"},{"@language":"ita","@value":"Documento PDF"}]}],"ebucore:filename":["animals-15-03238-v2.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/VKA6-9XTY"],"skos:prefLabel":[{"@language":"eng","@value":"journal article"},{"@language":"deu","@value":"Wissenschaftlicher Artikel"},{"@language":"ita","@value":"Articolo scientifico"}]}],"edm:rights":["http:\/\/creativecommons.org\/licenses\/by\/4.0\/"],"oaire:version":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/PMR8-3C8D"],"skos:prefLabel":[{"@language":"eng","@value":"version of record (published version)"},{"@language":"ita","@value":"Versione editoriale\/Version of Record"}]}],"rdam:P30004":[{"@type":"ids:doi","@value":"10.3390\/ani15223238"}],"rdau:P60193":[{"@type":"schema:CreativeWork","bibo:issue":[{"@value":"22"}],"bibo:volume":[{"@value":"15"}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Animals"}]}],"dcterms:issued":["2025"],"ids:issn":["2076-2615"]}],"role:aut":[{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Kristofova"}],"schema:givenName":[{"@value":"Radoslava"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-5169-2858"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animal and Food Systems Science, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria"}]}],"schema:familyName":[{"@value":"Zitterl-Eglseer"}],"schema:givenName":[{"@value":"Karin"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-6908-7074"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Biology, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA"}]}],"schema:familyName":[{"@value":"Firooznia"}],"schema:givenName":[{"@value":"Fardad"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Laukova"}],"schema:givenName":[{"@value":"Andrea"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0001-7413-3816"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Animal Production Research Centre, National Agricultural and Food Centre, Hlohovecka 2, 951 41 Nitra-Luzianky, Slovakia"}]}],"schema:familyName":[{"@value":"Chrastinova"}],"schema:givenName":[{"@value":"Lubica"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Pogany Simonova"}],"schema:givenName":[{"@value":"Monika"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-0377-4672"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Takacsova"}],"schema:givenName":[{"@value":"Margareta"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-7478-9177"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Bacova"}],"schema:givenName":[{"@value":"Kristina"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-1856-4475"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"Department of Digestive Tract Physiology, Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia"}]}],"schema:familyName":[{"@value":"Placha"}],"schema:givenName":[{"@value":"Iveta"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-8724-0159"}]}],"schema:numberOfPages":["14"]}