https://phaidra.vetmeduni.ac.at/o:4228 Feline primary nonhematopoietic malignant liver tumors: A multicenter retrospective study (2000-2021) Brandstetter, Viktoria Viktoria Brandstetter Schmidt, Jarno M Jarno M Schmidt Findji, Laurent Laurent Findji Selmic, Laura E. Laura E. Selmic Murgia, Daniela Daniela Murgia de Mello Souza, Carlos H Carlos H de Mello Souza Liehmann, Lea M Lea M Liehmann 0000-0002-5266-4971 University of Veterinary Medicine Vienna L' Eplattenier, Henry Henry L' Eplattenier Tichy, Alexander Alexander Tichy 0000-0001-8668-3858 University of Veterinary Medicine Vienna Vincenti, Simona Simona Vincenti Wiley journal article open access eng There is scant literature on primary nonhematopoietic malignant liver tumours (PMLT) in cats. In this retrospective study, medical data of 40 cats diagnosed with PMLT were reviewed over a period of 22 years (2000–2021). The most frequent epithelial tumours were hepatocellular (42.5%) and bile duct carcinomas (32.5%), only six (15%) cats had mesenchymal tumours. The median age was 13 years and clinical signs commonly included ano-/hyporexia (62.5%), apathy/lethargy (52.5%), weight loss (42.5%) and vomiting (35%). At initial diagnosis, metastases were confirmed in 1 (2.5%) and suspected in three (7.5%) cats. Massive was the most frequent morphology (75%). Most intrahepatic tumours were left-sided (54.2%) with the left medial lobe being primarily affected (25%). Extrahepatic tumours were rare (5%). In 34 (85%) cats, liver lobectomy was performed (surgery group), four (10%) were treated palliatively (non-surgery group), and two (5%) received no treatment. Intraoperative complications occurred in 11.8% with four (15.4%) postoperative deaths. Recurrence was detected in 28.6% at a median of 151 days (range, 79–684 days), while postoperative metastases were suspected in 21.4% at a median of 186 days (range, 79–479 days). The median survival time (MST) was significantly longer in cats of the surgery group (375 days) than in the non-surgery group (16 days) (p = .002). MST was 868 days for hepatocellular compared to 270 days for bile duct carcinomas (p = .06). In summary, liver lobectomy is associated with prolonged survival times and good prognosis in cats with hepatocellular, and an acceptable prognosis in cats with bile duct carcinoma. Cats Animals Retrospective Studies Prognosis Weight Loss Liver Neoplasms Surgery Liver Neoplasms Veterinary Carcinoma Veterinary Cat Diseases Diagnosis Cat Diseases Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:4228/download 10.1111/vco.12874 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Veterinary and Comparative Oncology issn:1476-5829 VoR Veterinary and Comparative Oncology 21 2 1.33 MB 2023