phaidra.vetmeduni.ac.at o:4228 DOI 10.1111/vco.12874 Feline primary nonhematopoietic malignant liver tumors: A multicenter retrospective study (2000-2021) There is scant literature on primary nonhematopoietic malignant liver tumours (PMLT) in cats. In this retrospective study, medical data of 40 cats diagnosed with PMLT were reviewed over a period of 22 years (2000–2021). The most frequent epithelial tumours were hepatocellular (42.5%) and bile duct carcinomas (32.5%), only six (15%) cats had mesenchymal tumours. The median age was 13 years and clinical signs commonly included ano-/hyporexia (62.5%), apathy/lethargy (52.5%), weight loss (42.5%) and vomiting (35%). At initial diagnosis, metastases were confirmed in 1 (2.5%) and suspected in three (7.5%) cats. Massive was the most frequent morphology (75%). Most intrahepatic tumours were left-sided (54.2%) with the left medial lobe being primarily affected (25%). Extrahepatic tumours were rare (5%). In 34 (85%) cats, liver lobectomy was performed (surgery group), four (10%) were treated palliatively (non-surgery group), and two (5%) received no treatment. Intraoperative complications occurred in 11.8% with four (15.4%) postoperative deaths. Recurrence was detected in 28.6% at a median of 151 days (range, 79–684 days), while postoperative metastases were suspected in 21.4% at a median of 186 days (range, 79–479 days). The median survival time (MST) was significantly longer in cats of the surgery group (375 days) than in the non-surgery group (16 days) (p = .002). MST was 868 days for hepatocellular compared to 270 days for bile duct carcinomas (p = .06). In summary, liver lobectomy is associated with prolonged survival times and good prognosis in cats with hepatocellular, and an acceptable prognosis in cats with bile duct carcinoma. eng Cats Animals Retrospective Studies Prognosis Weight Loss Liver Neoplasms Surgery Liver Neoplasms Veterinary Carcinoma Veterinary Cat Diseases Diagnosis Cat Diseases Surgery 2025-07-01T09:20:51.289Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Brandstetter;Viktoria; FN:Viktoria Brandstetter END:VCARD BEGIN:VCARD VERSION:3.0 N:Schmidt;Jarno M; FN:Jarno M Schmidt END:VCARD BEGIN:VCARD VERSION:3.0 N:Findji;Laurent; FN:Laurent Findji END:VCARD BEGIN:VCARD VERSION:3.0 N:Selmic;Laura E.; FN:Laura E. Selmic END:VCARD BEGIN:VCARD VERSION:3.0 N:Murgia;Daniela; FN:Daniela Murgia END:VCARD BEGIN:VCARD VERSION:3.0 N:de Mello Souza;Carlos H; FN:Carlos H de Mello Souza END:VCARD BEGIN:VCARD VERSION:3.0 N:Liehmann;Lea M; FN:Lea M Liehmann X-ORCID:https://orcid.org/0000-0002-5266-4971 END:VCARD BEGIN:VCARD VERSION:3.0 N:L' Eplattenier;Henry; FN:Henry L' Eplattenier END:VCARD BEGIN:VCARD VERSION:3.0 N:Tichy;Alexander; FN:Alexander Tichy X-ORCID:https://orcid.org/0000-0001-8668-3858 END:VCARD BEGIN:VCARD VERSION:3.0 N:Vincenti;Simona; FN:Simona Vincenti END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by-nc-nd/4.0 application/pdf 1391333 https://phaidra.vetmeduni.ac.at/o:4228 https://phaidra.vetmeduni.ac.at/api/object/o:4228/thumbnail LOMv1.0 discipline