https://phaidra.vetmeduni.ac.at/o:4027 Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome Giordano, Catello Catello Giordano Kendler, Jonatan Jonatan Kendler University of Veterinary Medicine Vienna Sexl, Maximilian Maximilian Sexl University of Veterinary Medicine Vienna Kollman, Sebastian Sebastian Kollman 0000-0001-7911-9896 University of Veterinary Medicine Vienna Varenicja, Maxim Maxim Varenicja Szabó, Boglárka Boglárka Szabó Timelthaler, Gerald Gerald Timelthaler Kirchhofer, Dominik Dominik Kirchhofer Hollóczki, Oldamur Oldamur Hollóczki Turner, Suzanne D. Suzanne D. Turner Moriggl, Richard Richard Moriggl 0000-0003-0918-9463 Kenner, Lukas Lukas Kenner 0000-0003-2184-1338 University of Veterinary Medicine Vienna Touaibia, Mohamed Mohamed Touaibia Merkel, Olaf Olaf Merkel Elsevier journal article open access eng Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal ?-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies. Humans Caffeic Acids Pharmacology Caffeic Acids Chemistry Phenylethyl Alcohol Analogs & Derivatives Phenylethyl Alcohol Pharmacology Phenylethyl Alcohol Chemistry Centrosome Drug Effects Centrosome Metabolism Antineoplastic Agents Pharmacology Antineoplastic Agents Chemistry Apoptosis Drug Effects Cell Line, Tumor Cell Proliferation Drug Effects http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:4027/download 10.1016/j.redox.2025.103582 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Redox Biology issn:2213-2317 VoR Redox Biology 81 5.54 MB 2025