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<lom:catalog>phaidra.vetmeduni.ac.at</lom:catalog>

  
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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1016/j.redox.2025.103582</lom:langstring>

  
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</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome</lom:langstring>

  
</lom:title>

  
<lom:description>
  
<lom:langstring xml:lang="en">Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal ?-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other
malignancies.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Humans</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Caffeic Acids Pharmacology</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Caffeic Acids Chemistry</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Phenylethyl Alcohol Analogs &amp; Derivatives</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Phenylethyl Alcohol Pharmacology</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Phenylethyl Alcohol Chemistry</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Centrosome Drug Effects</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Centrosome Metabolism</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Antineoplastic Agents Pharmacology</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Antineoplastic Agents Chemistry</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Apoptosis Drug Effects</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Cell Line, Tumor</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Cell Proliferation Drug Effects</lom:langstring>

  
</lom:keyword>

  
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<lom:datetime>2025-04-10T09:21:12.894Z</lom:datetime>

  
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<lom:langstring xml:lang="x-none">Author</lom:langstring>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Giordano;Catello;
FN:Catello Giordano
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</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Kendler;Jonatan;
FN:Jonatan Kendler
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Sexl;Maximilian;
FN:Maximilian Sexl
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N:Kollman;Sebastian;
FN:Sebastian Kollman
X-ORCID:https://orcid.org/0000-0001-7911-9896
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<lom:vcard>BEGIN:VCARD
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N:Varenicja;Maxim;
FN:Maxim Varenicja
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N:Szabó;Boglárka;
FN:Boglárka Szabó
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<lom:vcard>BEGIN:VCARD
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N:Timelthaler;Gerald;
FN:Gerald Timelthaler
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N:Kirchhofer;Dominik;
FN:Dominik Kirchhofer
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Hollóczki;Oldamur;
FN:Oldamur Hollóczki
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<lom:vcard>BEGIN:VCARD
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N:Turner;Suzanne D.;
FN:Suzanne D. Turner
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Moriggl;Richard;
FN:Richard Moriggl
X-ORCID:https://orcid.org/0000-0003-0918-9463
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<lom:centity>
  
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N:Kenner;Lukas;
FN:Lukas Kenner
X-ORCID:https://orcid.org/0000-0003-2184-1338
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Touaibia;Mohamed;
FN:Mohamed Touaibia
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Merkel;Olaf;
FN:Olaf Merkel
END:VCARD</lom:vcard>

  
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