https://phaidra.vetmeduni.ac.at/o:3912 Lethal Borna disease virus 1 infections of humans and animals - in-depth molecular epidemiology and phylogeography Ebinger, Arnt Arnt Ebinger Santos, Pauline D Pauline D Santos 0000-0003-4324-5967 Pfaff, Florian Florian Pfaff 0000-0003-0178-6183 Dürrwald, Ralf Ralf Dürrwald 0000-0002-3432-0438 Kolodziejek, Jolanta Jolanta Kolodziejek 0000-0001-5736-3644 Schlottau, Kore Kore Schlottau 0000-0002-3999-0393 Ruf, Viktoria Viktoria Ruf Liesche-Starnecker, Friederike Friederike Liesche-Starnecker 0000-0003-1948-1580 Ensser, Armin Armin Ensser 0000-0001-8873-3863 Korn, Klaus Klaus Korn 0000-0003-1891-2107 Ulrich, Reiner Reiner Ulrich Fürstenau, Jenny Jenny Fürstenau 0000-0001-5349-1403 Matiasek, Kaspar Kaspar Matiasek 0000-0001-5021-3280 Hansmann, Florian Florian Hansmann 0000-0001-6064-7728 Seuberlich, Torsten Torsten Seuberlich Nobach, Daniel Daniel Nobach 0000-0001-6279-7412 Müller, Matthias Matthias Müller Neubauer-Juric, Antonie Antonie Neubauer-Juric 0000-0002-9867-1261 Suchowski, Marcel Marcel Suchowski Bauswein, Markus Markus Bauswein Niller, Hans-Helmut Hans-Helmut Niller Schmidt, Barbara Barbara Schmidt Tappe, Dennis Dennis Tappe Cadar, Daniel Daniel Cadar Homeier-Bachmann, Timo Timo Homeier-Bachmann 0000-0002-8135-3814 Haring, Viola C. Viola C. Haring 0009-0007-7595-8239 Pörtner, Kirsten Kirsten Pörtner 0000-0001-8191-8056 Frank, Christina Christina Frank 0000-0001-6776-8450 Mundhenk, Lars Lars Mundhenk 0000-0002-9033-9360 Hoffmann, Bernd Bernd Hoffmann 0000-0001-5358-6445 Herms, Jochen Jochen Herms 0000-0002-6201-1042 Baumgärtner, Wolfgang Wolfgang Baumgärtner 0000-0001-8151-5644 Nowotny, Norbert Norbert Nowotny 0000-0002-3548-571X University of Veterinary Medicine Vienna Schlegel, Jürgen Jürgen Schlegel Ulrich, Rainer G. Rainer G. Ulrich 0000-0002-5620-1528 Beer, Martin Martin Beer 0000-0002-0598-5254 Rubbenstroth, Dennis Dennis Rubbenstroth 0000-0002-8209-6274 Nature Portfolio journal article open access eng Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis. BoDV-1 infection was confirmed by RT-qPCR in 207 domestic mammals, 28 humans and seven wild shrews. Thereby, this study markedly raises the number of published laboratory-confirmed human BoDV-1 infections and provides a first comprehensive summary. Generation of 136 new BoDV-1 genome sequences from animals and humans facilitated an in-depth phylogeographic analysis, allowing for the definition of risk areas for zoonotic BoDV-1 transmission and facilitating the assessment of geographical infection sources. Consistent with the low mobility of its reservoir host, BoDV-1 sequences showed a remarkable geographic association, with individual phylogenetic clades occupying distinct areas. The closest genetic relatives of most human-derived BoDV-1 sequences were located at distances of less than 40 km, indicating that spill-over transmission from the natural reservoir usually occurs in the patient´s home region. Animals Borna Disease Virus Genetics Borna Disease Virus Physiology Humans Borna Disease Epidemiology Borna Disease Virology Phylogeography Phylogeny Molecular Epidemiology Shrews Virology Female Male Germany Epidemiology Disease Reservoirs Virology Austria Epidemiology Zoonoses Epidemiology Zoonoses Virology Zoonoses Transmission Switzerland Epidemiology Adult Middle Aged Genome, Viral Genetics http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:3912/download 10.1038/s41467-024-52192-x https://phaidra.vetmeduni.ac.at/o:605 application/pdf Nature Communications issn:2041-1723 VoR Nature Communications 15 1 4.22 MB 2024