{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/spec\/#","frap":"http:\/\/purl.org\/cerif\/frapo","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"https:\/\/www.w3.org\/TR\/rdf-schema\/","relators":"http:\/\/id.loc.gov\/vocabulary\/relators","role":{"@context":{"aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"}}},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:3896","bf:note":[{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"The vital cell cycle machinery is tightly regulated and alterations of its central signaling hubs are a hallmark of cancer. The activity of CDK6 is controlled by interaction with several partners including cyclins and INK4 proteins, which have been shown to mainly bind to the amino-terminal lobe. We analyzed the impact of CDK6's C-terminus on its functions in a leukemia model, revealing a central role in promoting proliferation. C-terminally truncated Cdk6 (Cdk6 D C) shows reduced nuclear translocation and therefore chromatin interaction and fails to enhance proliferation and disease progression. The combination of proteomic analysis and protein modeling highlights that Cdk6's C-terminus is essential for protein flexibility and for its binding potential to cyclin D, p27 Kip1 and INK4 proteins but not cyclin B. We demonstrate that the C-terminus is a unique and essential part of the CDK6 protein, regulating interaction partner binding and therefore CDK6's functionality."}]}],"bf:provisionActivity":[{"@type":"bf:Publication","bf:agent":[{"@type":"schema:Organization","schema:name":[{"@value":"MDPI"}]}]}],"dce:rights":[{"@language":"eng","@value":"© 2025 The Authors"}],"dce:subject":[{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Cyclin-Dependent Kinase"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Cell-Cycle"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Structural Basis"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Crystal-Structure"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Intrinsic Disorder"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Protein-Structure"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Inhibitor"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Prediction"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Complex"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Links"}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Cdk6’s functions are critically regulated by its unique C-terminus"}]}],"dcterms:accessRights":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/QW5R-NG4J"],"skos:prefLabel":[{"@language":"eng","@value":"open access"}]}],"dcterms:issued":["2025"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"}]}],"ebucore:filename":["I_107956.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/VKA6-9XTY"],"skos:prefLabel":[{"@language":"eng","@value":"journal article"},{"@language":"deu","@value":"Wissenschaftlicher Artikel"}]}],"edm:rights":["http:\/\/creativecommons.org\/licenses\/by\/4.0\/"],"oaire:version":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/PMR8-3C8D"],"skos:prefLabel":[{"@language":"eng","@value":"version of record (published version)"}]}],"rdam:P30004":[{"@type":"ids:doi","@value":"10.1016\/j.isci.2024.111697"}],"rdau:P60193":[{"@type":"schema:CreativeWork","bibo:volume":["28"],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"iScience"}]}],"dcterms:issued":["2025"],"ids:issn":["2589-0042"]}],"role:aut":[{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Schirripa"}],"schema:givenName":[{"@value":"Alessia"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0001-5446-9136"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Schöppe"}],"schema:givenName":[{"@value":"Helge"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Nebenfuehr"}],"schema:givenName":[{"@value":"Sofie"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Zojer"}],"schema:givenName":[{"@value":"Markus"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Klampfl"}],"schema:givenName":[{"@value":"Thorsten"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-6666-9773"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Kugler"}],"schema:givenName":[{"@value":"Valentina"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Maw"}],"schema:givenName":[{"@value":"Belinda S."}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-1881-0883"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Ceylan"}],"schema:givenName":[{"@value":"Huriye"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Uras"}],"schema:givenName":[{"@value":"Iris Z."}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Scheiblecker"}],"schema:givenName":[{"@value":"Lisa"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Gamper"}],"schema:givenName":[{"@value":"Elisabeth"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Stelzl"}],"schema:givenName":[{"@value":"Ulrich"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Stefan"}],"schema:givenName":[{"@value":"Eduard"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Kaserer"}],"schema:givenName":[{"@value":"Teresa"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Sexl"}],"schema:givenName":[{"@value":"Veronika"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0001-9363-0412"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Kollmann"}],"schema:givenName":[{"@value":"Karoline"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0002-7937-4245"}]}],"schema:numberOfPages":["22"]}