
<lom:lom xmlns:lom="https://oer-repo.uibk.ac.at/lom" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://oer-repo.uibk.ac.at/lom/latest https://w3id.org/oerbase/profiles/lomuibk/latest/schemas/lom-uibk.xsd">
  
<lom:general>
  
<lom:identifier>
  
<lom:catalog>phaidra.vetmeduni.ac.at</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">o:3873</lom:langstring>

  
</lom:entry>

  
</lom:identifier>

  
<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1038/s44221-024-00297-4</lom:langstring>

  
</lom:entry>

  
</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom</lom:langstring>

  
</lom:title>

  
<lom:description>
  
<lom:langstring xml:lang="en">Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and &gt;120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.</lom:langstring>

  
</lom:description>

  
<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Effluents</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Water</lom:langstring>

  
</lom:keyword>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Risk</lom:langstring>

  
</lom:keyword>

  
</lom:general>

  
<lom:lifecycle>
  
<lom:datetime>2025-02-20T08:57:51.029Z</lom:datetime>

  
<lom:contribute>
  
<lom:role>
  
<lom:source>
  
<lom:langstring xml:lang="x-none">LOMv1.0</lom:langstring>

  
</lom:source>

  
<lom:value>
  
<lom:langstring xml:lang="x-none">Author</lom:langstring>

  
</lom:value>

  
</lom:role>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Escher;Beate I.;
FN:Beate I. Escher
X-ORCID:https://orcid.org/0000-0002-5304-706X
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Ahlheim;Jörg;
FN:Jörg Ahlheim
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Böhme;Alexander;
FN:Alexander Böhme
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Borchardt;Dietrich;
FN:Dietrich Borchardt
X-ORCID:https://orcid.org/0000-0002-6074-2829
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Brack;Werner;
FN:Werner Brack
X-ORCID:https://orcid.org/0000-0001-9269-6524
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Braun;Georg;
FN:Georg Braun
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Colbourne;John K.;
FN:John K. Colbourne
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Dann;Janek Paul;
FN:Janek Paul Dann
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Gessner;Joern;
FN:Joern Gessner
X-ORCID:https://orcid.org/0000-0002-1675-0549
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Jahnke;Annika;
FN:Annika Jahnke
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:König;Maria;
FN:Maria König
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Klüver;Nils;
FN:Nils Klüver
X-ORCID:https://orcid.org/0000-0002-8045-9473
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Krauss;Martin;
FN:Martin Krauss
X-ORCID:https://orcid.org/0000-0002-0362-4244
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Lee;Jungeun;
FN:Jungeun Lee
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Li;Xiaojing;
FN:Xiaojing Li
X-ORCID:https://orcid.org/0000-0002-2796-5342
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Lips;Stefan;
FN:Stefan Lips
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Orsini;Luisa;
FN:Luisa Orsini
X-ORCID:https://orcid.org/0000-0002-1716-5624
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Rinke;Karsten;
FN:Karsten Rinke
X-ORCID:https://orcid.org/0000-0003-0864-6722
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Schmitt-Jansen;Mechthild;
FN:Mechthild Schmitt-Jansen
X-ORCID:https://orcid.org/0000-0002-4541-6515
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Scholz;Stefan;
FN:Stefan Scholz
X-ORCID:https://orcid.org/0000-0002-6990-4716
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Schulze;Tobias;
FN:Tobias Schulze
X-ORCID:https://orcid.org/0000-0002-9744-8914
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Spahr;Stephanie;
FN:Stephanie Spahr
X-ORCID:https://orcid.org/0000-0002-3004-3162
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Ulrich;Nadin;
FN:Nadin Ulrich
X-ORCID:https://orcid.org/0000-0002-1267-0429
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Weitere;Markus;
FN:Markus Weitere
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Varga;Elisabeth;
FN:Elisabeth Varga
X-ORCID:https://orcid.org/0000-0001-6046-3259
END:VCARD</lom:vcard>

  
</lom:centity>

  
</lom:contribute>

  
</lom:lifecycle>

  
<lom:educational>
  
<lom:learningresourcetype>
  
<lom:source>
  
<lom:langstring xml:lang="x-none">https://w3id.org/kim/hcrt/scheme</lom:langstring>

  
</lom:source>

  
<lom:id>https://w3id.org/kim/hcrt/text</lom:id>

  
<lom:entry>
  
<lom:langstring xml:lang="de">Textdokument</lom:langstring>

  
<lom:langstring xml:lang="en">Text</lom:langstring>

  
</lom:entry>

  
</lom:learningresourcetype>

  
</lom:educational>

  
<lom:rights>
  
<lom:copyrightandotherrestrictions>
  
<lom:source>
  
<lom:langstring xml:lang="x-none">LOMv1.0</lom:langstring>

  
</lom:source>

  
<lom:value>
  
<lom:langstring xml:lang="x-none">yes</lom:langstring>

  
</lom:value>

  
</lom:copyrightandotherrestrictions>

  
<lom:description>
  
<lom:langstring xml:lang="x-t-cc-url">https://creativecommons.org/licenses/by/4.0</lom:langstring>

  
</lom:description>

  
</lom:rights>

  
<lom:technical>
  
<lom:format>application/pdf</lom:format>

  
<lom:size>1295136</lom:size>

  
<lom:location>https://phaidra.vetmeduni.ac.at/o:3873</lom:location>

  
<lom:thumbnail>
  
<lom:url>https://phaidra.vetmeduni.ac.at/api/object/o:3873/thumbnail</lom:url>

  
</lom:thumbnail>

  
</lom:technical>

  
<lom:classification>
  
<lom:purpose>
  
<lom:source>
  
<lom:langstring xml:lang="x-none">LOMv1.0</lom:langstring>

  
</lom:source>

  
<lom:value>
  
<lom:langstring xml:lang="x-none">discipline</lom:langstring>

  
</lom:value>

  
</lom:purpose>

  
</lom:classification>

  
</lom:lom>