
<resource xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:datacite="http://datacite.org/schema/kernel-4" xmlns="http://namespace.openaire.eu/schema/oaire/" xsi:schemaLocation="http://namespace.openaire.eu/schema/oaire/ https://www.openaire.eu/schema/repo-lit/4.0/openaire.xsd">
  
<datacite:identifier identifierType="URL">https://phaidra.vetmeduni.ac.at/o:3859</datacite:identifier>

  
<datacite:titles>
  
<datacite:title xml:lang="en">Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts</datacite:title>

  
</datacite:titles>

  
<datacite:creators>
  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Varaka, Maria</datacite:creatorName>

  
<datacite:givenName>Maria</datacite:givenName>

  
<datacite:familyName>Varaka</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-1113-5907</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Merkle, Conrad W.</datacite:creatorName>

  
<datacite:givenName>Conrad W.</datacite:givenName>

  
<datacite:familyName>Merkle</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">May, Lucas</datacite:creatorName>

  
<datacite:givenName>Lucas</datacite:givenName>

  
<datacite:familyName>May</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Fanjul-Vélez, Félix</datacite:creatorName>

  
<datacite:givenName>Félix</datacite:givenName>

  
<datacite:familyName>Fanjul-Vélez</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Worm, Sybren</datacite:creatorName>

  
<datacite:givenName>Sybren</datacite:givenName>

  
<datacite:familyName>Worm</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0009-0008-3243-4491</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Augustin, Marco</datacite:creatorName>

  
<datacite:givenName>Marco</datacite:givenName>

  
<datacite:familyName>Augustin</datacite:familyName>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Lee, Hsiang-Chieh</datacite:creatorName>

  
<datacite:givenName>Hsiang-Chieh</datacite:givenName>

  
<datacite:familyName>Lee</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-2976-6195</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Wöhrer, Adelheid</datacite:creatorName>

  
<datacite:givenName>Adelheid</datacite:givenName>

  
<datacite:familyName>Wöhrer</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-8435-8189</datacite:nameIdentifier>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Glösmann, Martin</datacite:creatorName>

  
<datacite:givenName>Martin</datacite:givenName>

  
<datacite:familyName>Glösmann</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-2094-3247</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Baumann, Bernhard</datacite:creatorName>

  
<datacite:givenName>Bernhard</datacite:givenName>

  
<datacite:familyName>Baumann</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-6419-1932</datacite:nameIdentifier>

  
</datacite:creator>

  
</datacite:creators>

  
<dc:publisher>Spie</dc:publisher>

  
<resourceType resourceTypeGeneral="literature" uri="http://purl.org/coar/resource_type/c_6501">journal article</resourceType>

  
<datacite:rights rightsURI="http://purl.org/coar/access_right/c_abf2">open access</datacite:rights>

  
<dc:language>eng</dc:language>

  
<dc:description xml:lang="en">Optical coherence tomography (OCT) images are prone to image artifacts due to the birefringence of the sample or the optical system when a polarized light source is used for imaging. These artifacts can lead to degraded image quality and diagnostic information.We aim to mitigate these birefringence-related artifacts in OCT images by adding a depolarizer module in the reference arm of the interferometer.We investigated different configurations of liquid crystal patterned retarders as pseudo-depolarizers in the reference arm of OCT setups. We identified the most effective depolarization module layout for polarization artifact suppression for a spectral-domain OCT system based on a Michelson and a Mach-Zehnder interferometer.The performance of our approach was demonstrated in an achromatic quarter-wave plate allowing the selection of a variety of sample polarization states. A substantial improvement of the OCT signal magnitude was observed after placing the optimal depolarizer configuration, reducing the cross-polarization artifact from 5.7 to 1.8 dB and from 8.0 to 1.0 dB below the co-polarized signal for the fiber-based Michelson and Mach-Zehnder setup, respectively. An imaging experiment in the birefringent scleral tissue of a post-mortem alpine marmot eye and a mouse tail specimen further showcased a significant improvement in the detected signal intensity and an enhanced OCT image quality followed by a drastic elimination of the birefringence-related artifacts.Our study presents a simple yet cost-effective technique to mitigate birefringence-related artifacts in OCT imaging. This method can be readily implemented in existing OCT technology and improve the effectiveness of various OCT imaging applications in biomedicine.</dc:description>

  
<datacite:subjects>
  
<datacite:subject xml:lang="en">Tomography, Optical Coherence Methods</datacite:subject>

  
<datacite:subject xml:lang="en">Tomography, Optical Coherence Instrumentation</datacite:subject>

  
<datacite:subject xml:lang="en">Birefringence</datacite:subject>

  
<datacite:subject xml:lang="en">Artifacts</datacite:subject>

  
<datacite:subject xml:lang="en">Animals</datacite:subject>

  
<datacite:subject xml:lang="en">Mice</datacite:subject>

  
<datacite:subject xml:lang="en">Equipment Design</datacite:subject>

  
<datacite:subject xml:lang="en">Interferometry Methods</datacite:subject>

  
<datacite:subject xml:lang="en">Interferometry Instrumentation</datacite:subject>

  
<datacite:subject xml:lang="en">Image Processing, Computer-Assisted Methods</datacite:subject>

  
</datacite:subjects>

  
<licenseCondition uri="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</licenseCondition>

  
<file accessRightsURI="http://purl.org/coar/access_right/c_abf2" mimeType="application/pdf" objectType="fulltext">https://phaidra.vetmeduni.ac.at/api/object/o:3859/download</file>

  
<datacite:alternateIdentifiers>
  
<datacite:alternateIdentifier alternateIdentifierType="DOI">10.1117/1.JBO.29.11.116001</datacite:alternateIdentifier>

  
</datacite:alternateIdentifiers>

  
<datacite:relatedIdentifiers>
  
<datacite:relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://phaidra.vetmeduni.ac.at/o:605</datacite:relatedIdentifier>

  
</datacite:relatedIdentifiers>

  
<dc:format>application/pdf</dc:format>

  
<dc:source xml:lang="en">Journal of Biomedical Optics</dc:source>

  
<dc:source>issn:1560-2281</dc:source>

  
<version uri="http://purl.org/coar/version/c_970fb48d4fbd8a85">VoR</version>

  
<citationTitle>Journal of Biomedical Optics</citationTitle>

  
<citationVolume>29</citationVolume>

  
<citationIssue>11</citationIssue>

  
<datacite:sizes>
  
<datacite:size>5.16 MB</datacite:size>

  
</datacite:sizes>

  
<datacite:dates>
  
<datacite:date dateType="Issued">2024</datacite:date>

  
</datacite:dates>

  
</resource>