https://phaidra.vetmeduni.ac.at/o:3825 Clinical findings, treatment, and outcomes in cats with naturally occurring hypoadrenocorticism: 41 cases Roberts, Emma Emma Roberts 0000-0002-3157-9671 Ramsey, Ian K. Ian K. Ramsey 0000-0002-7379-9488 Gostelow, Ruth Ruth Gostelow 0000-0001-9354-8291 Latysheva, Anna Anna Latysheva Battaglia, Luca Luca Battaglia Silvestrini, Paolo Paolo Silvestrini 0000-0003-3671-5350 Benchekroun, Ghita Ghita Benchekroun 0000-0003-3947-5655 Brenner, Karen Karen Brenner Conversy, Bérénice Bérénice Conversy Ferriani, Riccardo Riccardo Ferriani 0000-0002-8862-5317 Kortum, Andre Andre Kortum 0000-0002-9760-733X Stammeleer, Lisa Lisa Stammeleer Van den Steen, Nele Nele Van den Steen Tavares, Flavia Flavia Tavares Lieser, Julia Julia Lieser Hibbert, Angie Angie Hibbert Duclos, Antoine Antoine Duclos 0009-0008-8957-6108 Bunn, Troy Troy Bunn 0000-0001-6812-6310 Boag, Alisdair M. Alisdair M. Boag 0000-0002-3819-1821 Arenas, Carolina Carolina Arenas 0000-0002-5071-7689 Roe, Kirsty Kirsty Roe Zeugswetter, Florian K. Florian K. Zeugswetter 0000-0001-5944-0375 University of Veterinary Medicine Vienna Cui, Yi Yi Cui Schofield, Imogen Imogen Schofield Fracassi, Federico Federico Fracassi 0000-0003-3121-2199 Wiley journal article open access eng Hypoadrenocorticism in cats is uncommonly reported. Most reports consist of cats with hyponatremia, hyperkalemia, or both.To describe clinical findings, treatment response, and outcome in cats diagnosed with hypoadrenocorticism, including cats with abnormal and normal serum sodium and potassium concentrations.Forty-one cats with hypoadrenocorticism; 36 with and 5 without abnormal serum sodium and potassium concentrations.Multicenter retrospective observational study. Data for the entire cohort were assessed using descriptive statistics and differences between cats with and without abnormal serum sodium and potassium concentrations were evaluated.Median age was 5.7?years (range, 0.2-13.8). Twenty-three (56%) cats were male and 18 (44%) were female. Cats with hyponatremia, hyperkalemia, or both were less likely to have a history of vomiting (P?=?.01) but more likely to be hypothermic (P?=?.03), dehydrated (P?=?.04) or weak (P?=?.04) on examination, compared with nonhyponatremic and nonhyperkalemic cats. Frequency of hypercalcemia was 31.7%. Exocrine pancreatic insufficiency (EPI) was diagnosed in 4/7 cats tested; all 4 had concurrent cobalamin deficiency. Thirty-five (85.4%) cats survived to discharge. In 2 cats, hypoadrenocorticism occurred secondary to lymphoma. Median survival time (MST) for all-cause mortality was 2035?days (95% confidence interval [CI], 294-4380?days); MST for disease-specific mortality was not reached.Approximately one-third of cats with hypoadrenocorticism had hypercalcemia. In some cases, hyponatremia and hyperkalemia were not observed. Cats with nonneoplastic associated hypoadrenocorticism that survive initial hospitalization can have a favorable long-term prognosis. Testing for EPI may be warranted in cats with hypoadrenocorticism. Animals Cats Cat Diseases Therapy Female Male Retrospective Studies Hyponatremia Veterinary Hyponatremia Etiology Hyponatremia Therapy Adrenal Insufficiency Adrenal Veterinary Hyperkalemia Veterinary Hyperkalemia Therapy Sodiumblood Hypercalcemia Veterinary Hypercalcemia Therapy Potassiumblood Treatment Outcome http://creativecommons.org/licenses/by-nc-nd/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:3825/download 10.1111/jvim.17243 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Journal of Veterinary Internal Medicine issn:1939-1676 VoR Journal of Veterinary Internal Medicine 39 1 3.46 MB 2025