Emma Roberts Emma Roberts Ian K. Ramsey Ian K. Ramsey Ruth Gostelow Ruth Gostelow Anna Latysheva Anna Latysheva Luca Battaglia Luca Battaglia Paolo Silvestrini Paolo Silvestrini Ghita Benchekroun Ghita Benchekroun Karen Brenner Karen Brenner Bérénice Conversy Bérénice Conversy Riccardo Ferriani Riccardo Ferriani Andre Kortum Andre Kortum Lisa Stammeleer Lisa Stammeleer Nele Van den Steen Nele Van den Steen Flavia Tavares Flavia Tavares Julia Lieser Julia Lieser Angie Hibbert Angie Hibbert Antoine Duclos Antoine Duclos Troy Bunn Troy Bunn Alisdair M. Boag Alisdair M. Boag Carolina Arenas Carolina Arenas Kirsty Roe Kirsty Roe Florian K. Zeugswetter Florian K. Zeugswetter Yi Cui Yi Cui Imogen Schofield Imogen Schofield Federico Fracassi Federico Fracassi Wiley 2025 Hypoadrenocorticism in cats is uncommonly reported. Most reports consist of cats with hyponatremia, hyperkalemia, or both.To describe clinical findings, treatment response, and outcome in cats diagnosed with hypoadrenocorticism, including cats with abnormal and normal serum sodium and potassium concentrations.Forty-one cats with hypoadrenocorticism; 36 with and 5 without abnormal serum sodium and potassium concentrations.Multicenter retrospective observational study. Data for the entire cohort were assessed using descriptive statistics and differences between cats with and without abnormal serum sodium and potassium concentrations were evaluated.Median age was 5.7?years (range, 0.2-13.8). Twenty-three (56%) cats were male and 18 (44%) were female. Cats with hyponatremia, hyperkalemia, or both were less likely to have a history of vomiting (P?=?.01) but more likely to be hypothermic (P?=?.03), dehydrated (P?=?.04) or weak (P?=?.04) on examination, compared with nonhyponatremic and nonhyperkalemic cats. Frequency of hypercalcemia was 31.7%. Exocrine pancreatic insufficiency (EPI) was diagnosed in 4/7 cats tested; all 4 had concurrent cobalamin deficiency. Thirty-five (85.4%) cats survived to discharge. In 2 cats, hypoadrenocorticism occurred secondary to lymphoma. Median survival time (MST) for all-cause mortality was 2035?days (95% confidence interval [CI], 294-4380?days); MST for disease-specific mortality was not reached.Approximately one-third of cats with hypoadrenocorticism had hypercalcemia. In some cases, hyponatremia and hyperkalemia were not observed. Cats with nonneoplastic associated hypoadrenocorticism that survive initial hospitalization can have a favorable long-term prognosis. Testing for EPI may be warranted in cats with hypoadrenocorticism. PDFDocument eng 2025-01-29T09:29:50.024844Z 2025 Animals Cats Cat Diseases Therapy Female Male Retrospective Studies Hyponatremia Veterinary Hyponatremia Etiology Hyponatremia Therapy Adrenal Insufficiency Adrenal Veterinary Hyperkalemia Veterinary Hyperkalemia Therapy Sodiumblood Hypercalcemia Veterinary Hypercalcemia Therapy Potassiumblood Treatment Outcome 3624904 b application/pdf http://creativecommons.org/licenses/by-nc-nd/4.0/