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<edm:dataProvider>University of Veterinary Medicine Vienna</edm:dataProvider>

  
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<dc:title xml:lang="en">Vaccination strategies to protect chickens from fowl adenovirus (FAdV)-induced diseases: A comprehensive review</dc:title>

  
<dc:description xml:lang="en">In recent years, fowl adenovirus (FAdV)-induced diseases became a global problem with considerable impact on chicken health and welfare. This has prompted numerous studies to focus on experimental immunization strategies using whole virus formulations (live or killed vaccines), some of them modified as recombinantly constructed vector vaccines. In addition, FAdV capsid proteins were frequently reported as immunizing antigens (subunit vaccines), with fiber proteins being amongst the most successful candidates. To date, there is no standardized protocol to assess vaccine efficacy in experimental FAdV protection studies, with the consequence that the experimental settings present several degrees of variations even when sharing similar premises. Differences in formulation preparations, route of inoculation, antigen dose, vaccination scheme, choice of challenge strain, or type and age of the birds are capable to greatly influence the magnitude of the immune response and the consequent protective efficacy, altogether addressing remaining challenges.
Beyond the antigen composition of a vaccine, the epidemiology of FAdVs with the potential of vertical transmission of virus and/or antibodies from breeders to progenies has a substantial impact on protection strategies. The goal of this review is to outline a broad overview of the findings made thus far regarding immunization strategies against diseases associated to FAdV infections, considering the literature published since the appearance of hepatitis-hydropericardium syndrome (HHS) in the late Eighties, in order to emphasize the current knowledge on FAdV vaccines and highlight fields of future research and intervention.</dc:description>

  
<dc:identifier rdf:resource="https://phaidra.vetmeduni.ac.at/o:3805"></dc:identifier>

  
<dc:language>en</dc:language>

  
<edm:type>TEXT</edm:type>

  
<dc:type>journal article</dc:type>

  
<dc:type>Wissenschaftlicher Artikel</dc:type>

  
<dc:type xml:lang="en">Text</dc:type>

  
<dc:type xml:lang="en">journal article</dc:type>

  
<dc:type xml:lang="de">Text</dc:type>

  
<dc:type xml:lang="de">Wissenschaftlicher Artikel</dc:type>

  
<dc:subject xml:lang="en">Animals</dc:subject>

  
<dc:subject xml:lang="en">Chickens Immunology</dc:subject>

  
<dc:subject xml:lang="en">Poultry Diseases Prevention &amp; Control</dc:subject>

  
<dc:subject xml:lang="en">Poultry Diseases Immunology</dc:subject>

  
<dc:subject xml:lang="en">Poultry Diseases Virology</dc:subject>

  
<dc:subject xml:lang="en">Adenoviridae Infections Prevention &amp; Control</dc:subject>

  
<dc:subject xml:lang="en">Adenoviridae Infections Immunology</dc:subject>

  
<dc:subject xml:lang="en">Adenoviridae Infections Veterinary</dc:subject>

  
<dc:subject xml:lang="en">Vaccination Methods</dc:subject>

  
<dc:subject xml:lang="en">Viral Vaccines Immunology</dc:subject>

  
<dc:subject xml:lang="en">Viral Vaccines Administration &amp; dosage</dc:subject>

  
<dc:subject xml:lang="en">Aviadenovirus Immunology</dc:subject>

  
<dc:subject xml:lang="en">Aviadenovirus Genetics</dc:subject>

  
<dc:subject xml:lang="en">Capsid Proteins Immunology</dc:subject>

  
<dc:subject xml:lang="en">Capsid Proteins Genetics</dc:subject>

  
<dc:subject xml:lang="en">Fowl adenovirus Aimmunology</dc:subject>

  
<dc:subject xml:lang="en">Adenovirus Vaccines Immunology</dc:subject>

  
<dc:subject xml:lang="en">Adenovirus Vaccines Administration &amp; Dosage</dc:subject>

  
<dcterms:issued>2024</dcterms:issued>

  
<dc:date>2024</dc:date>

  
<dc:creator>Carlotta De Luca</dc:creator>

  
<dc:creator>Michael Hess</dc:creator>

  
<dc:publisher>Elsevier</dc:publisher>

  
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