Science Advances American Association for the Advancement of Science Animals Brain Microbiology Homeostasis Microbiota Salmonidae Microbiology RNA Ribosomal 16S Genetics Phylogeny Bacteria Classification Genetics Isolation & Purification Text journal article http://creativecommons.org/licenses/by-nc/4.0/ 2024 Amir Mani Cory Henn Claire Couch Sonal Patel Thora Lieke Justin T. H. Chan Tomas Korytar Irene Salinas Text Wissenschaftlicher Artikel application/pdf Copyright © 2024 The Authors open access A brain microbiome in salmonids at homeostasis Ectotherms have peculiar relationships with microorganisms. For instance, bacteria are recovered from the blood and internal organs of healthy teleosts. However, the presence of microbial communities in the healthy teleost brain has not been proposed. Here, we report a living bacterial community in the brain of healthy salmonids with bacterial loads comparable to those of the spleen and 1000-fold lower than in the gut. Brain bacterial communities share >50% of their diversity with gut and blood bacterial communities. Using culturomics, we obtained 54 bacterial isolates from the brains of healthy trout. Comparative genomics suggests that brain bacteria may have adaptations for niche colonization and polyamine biosynthesis. In a natural system, Chinook salmon brain microbiomes shift from juveniles to reproductively mature adults. Our study redefines the physiological relationships between the brain and bacteria in teleosts. This symbiosis may endow salmonids with a direct mechanism to sense and respond to environmental microbes. doi:10.1126/sciadv.ado0277 eng https://phaidra.vetmeduni.ac.at/o:3718