o:3364 European Competence Network on Mastocytosis (ECNM): 20-Year Jubilee, Updates, and Future Perspectives en In 2002, the European Competence Network on Mastocytosis (ECNM) was launched as a multidisciplinary collaborative initiative to increase the awareness and to improve diagnosis and management of patients with mast cell (MC) disorders. The ECNM consists of a net of specialized centers, expert physicians, and scientists who dedicate their work to MC diseases. One essential aim of the ECNM is to timely distribute all available information about the disease to patients, doctors, and scientists. In the past 20 years, the ECNM has expanded substantially and contributed successfully to the development of new diagnostic concepts, and to the classification, prognostication, and treatments of patients with mastocytosis and MC activation disorders. The ECNM also organized annual meetings and several working conferences, thereby supporting the development of the World Health Organization classification between 2002 and 2022. In addition, the ECNM established a robust and rapidly expanding patient registry and supported the development of new prognostic scoring systems and new treatment approaches. In all projects, ECNM representatives collaborated closely with their U.S. colleagues, various patient organizations, and other scientific networks. Finally, ECNM members have started several collaborations with industrial partners, leading to the preclinical development and clinical testing of KIT-targeting drugs in systemic mastocytosis, and some of these drugs received licensing approval in recent years. All these networking activities and collaborations have strengthened the ECNM and supported our efforts to increase awareness of MC disorders and to improve diagnosis, prognostication, and therapy in patients. Humans; Mastocytosis Diagnosis Therapy; Mastocytosis, Systemic Diagnosis; Forecasting; Mast Cells 1552099 10.1016/j.jaip.2023.02.021 2024-08-12T09:45:46.184Z 44 yes 46 Peter Valent Medical University of Vienna Karin Hartmann University of Basel / University Hospital of Basel person Patrizia Bonadonna Verona University Hospital person Wolfgang R. Sperr Medical University of Vienna person Marek Niedoszytko Gdańsk Medical University person Olivier Hermine person Hanneke C. Kluin-Nelemans University of Groningen person Karl Sotlar Paracelsus Medical University person Gregor Hoermann Medical University of Vienna / Munich Leukemia Laboratory (Germany) person Boguslaw Nedoszytko Gdańsk Medical University person Sigurd Broesby-Olsen Odense University Hospital person Roberta Zanotti University Hospital of Verona person Magdalena Lange Gdańsk Medical University person Michael Doubek University Hospital Brno / Masaryk University person Knut Brockow Technical University of Munich person Ivan Alvarez-Twose Hospital Virgen del Valle person Judit Varkonyi Semmelweis University person Selim Yavuz Istanbul University person Gunnar Nilsson person Deepti Radia Guy's Hospital person Clive Grattan Guy's Hospital person Juliana Schwaab University Hospital Mannheim person Theo Gülen Karolinska University Hospital / Karolinska Institutet person Hanneke N. G. Oude Elberink University of Groningen person Hans Hägglund Uppsala University Hospital person Frank Siebenhaar Charité - Universitätsmedizin Berlin / Fraunhofer Institute for Translational Medicine and Pharmacology person Emir Hadzijusufovic University of Veterinary Medicine Vienna / Medical University of Vienna person 0000-0001-7409-4204 Vito Sabato University of Antwerp / Antwerp University Hospital person Jiri Mayer University Hospital Brno / Masaryk University person Andreas Reiter University Hospital Mannheim person Alberto Orfao Universidad de Salamanca person Hans-Peter Horny Ludwig-Maximilians-Universität München person Massimo Triggiani University of Salerno person Michel Arock Sorbonne Université person application/pdf 637182 https://phaidra.vetmeduni.ac.at/o:3364 no yes 16 70 1552253 Journal of Allergy and Clinical Immunology - In Practice 12 11 6 1706 1717 Elsevier 2023