https://phaidra.vetmeduni.ac.at/o:3333 Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology Roth-Walter, Franziska Franziska Roth-Walter 0000-0001-5005-9228 University of Veterinary Medicine, Vienna / Medical University of Vienna Stellato, C. C. Stellato 0000-0002-1294-8355 University of Salerno Van Esch, B. C. A. M. B. C. A. M. Van Esch 0000-0001-9961-750X Utrecht University Sokolowska, M. M. Sokolowska 0000-0001-9710-6685 University of Zurich / CK-CARE Redegeld, F. F. Redegeld 0000-0001-8830-7960 Utrecht University Palomares, O. O. Palomares 0000-0003-4516-0369 Universidad Complutense de Madrid O'Mahony, L. L. O'Mahony 0000-0003-4705-3583 University College Cork Nocentini, G. G. Nocentini 0000-0002-5209-0488 University of Perugia Levi-Schaffer, F. F. Levi-Schaffer Hebrew University of Jerusalem Jesenak, M. M. Jesenak 0000-0001-7976-2523 Comenius University Bratislava Kohl, E. F. E. F. Kohl 0000-0001-7368-9820 University Medical Center Utrecht Eguiluz-Gracia, I. I. Eguiluz-Gracia 0000-0002-3774-931X Instituto de Investigación Biomédica de Málaga Diamant, Z. Z. Diamant 0000-0003-0133-0100 Skåne University Hospital / Charles University / University of Groningen Adcock, I. M. I. M. Adcock 0000-0003-2101-8843 Imperial College London Benito-Villalvilla, C. C. Benito-Villalvilla 0000-0002-5544-0199 Universidad Complutense de Madrid Bianchini, Rodolfo Rodolfo Bianchini 0000-0003-0351-6937 University of Veterinary Medicine Vienna Bjermer, L. L. Bjermer 0000-0002-3441-8099 Lund University Caramori, G. G. Caramori 0000-0002-9807-327X University of Parma Cari, L. L. Cari 0000-0003-0698-3872 University of Perugia Chung, K. F. K. F. Chung 0000-0001-7101-1426 Imperial College London Wiley text eng The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chiefly involved in the pathophysiology of allergic and other immune-driven diseases. Altered cell metabolism is also a hallmark of cell senescence, a condition characterized by loss of proliferative activity in cells that remain metabolically active. Accelerated senescence can be triggered by acute or chronic stress and inflammatory responses. In contrast, replicative senescence occurs as part of the physiological aging process and has protective roles in cancer surveillance and wound healing. Importantly, cell senescence can also change or hamper response to diverse therapeutic treatments. Understanding the metabolic pathways of senescence in immune and structural cells is therefore critical to detect, prevent, or revert detrimental aspects of senescence-related immunopathology, by developing specific diagnostics and targeted therapies. In this paper, we review the main changes and metabolic alterations occurring in senescent immune cells (macrophages, B cells, T cells). Subsequently, we present the metabolic footprints described in translational studies in patients with chronic asthma and chronic obstructive pulmonary disease (COPD), and review the ongoing preclinical studies and clinical trials of therapeutic approaches aiming at targeting metabolic pathways to antagonize pathological senescence. Because this is a recently emerging field in allergy and clinical immunology, a better understanding of the metabolic profile of the complex landscape of cell senescence is needed. The progress achieved so far is already providing opportunities for new therapies, as well as for strategies aimed at disease prevention and supporting healthy aging. Humans; Cellular Senescence Drug Effects; Metabolic Networks and Pathways; Animals; Chronic Disease; Inflammation Metabolism Immunology; Lung Diseases Etiology Drug Therapy Metabolism Immunology; Pulmonary Disease, Chronic Obstructive Metabolism Drug Therapy Immunology; Aging Immunology Metabolism http://creativecommons.org/licenses/by-nc/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:3333/download 10.1111/all.15977 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Allergy 79(5), 1089-1122 (2023) Allergy 79 5 1089 1122 2.03 MB 2023