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<datacite:identifier identifierType="URL">https://phaidra.vetmeduni.ac.at/o:3301</datacite:identifier>

  
<datacite:titles>
  
<datacite:title xml:lang="en">Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species</datacite:title>

  
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<datacite:creatorName nameType="Personal">Klughammer, Johanna</datacite:creatorName>

  
<datacite:givenName>Johanna</datacite:givenName>

  
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<datacite:affiliation>CeMM Research Center for Molecular Medicine / Ludwig-Maximilians-Universität München</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Bock, Christoph</datacite:creatorName>

  
<datacite:givenName>Christoph</datacite:givenName>

  
<datacite:familyName>Bock</datacite:familyName>

  
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<datacite:affiliation>CeMM Research Center for Molecular Medicine / Medical University of Vienna</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Kübber-Heiss, Anna</datacite:creatorName>

  
<datacite:givenName>Anna</datacite:givenName>

  
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<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Distel, Daniel L.</datacite:creatorName>

  
<datacite:givenName>Daniel L.</datacite:givenName>

  
<datacite:familyName>Distel</datacite:familyName>

  
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<datacite:affiliation>Northeastern University</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Distel, Martin</datacite:creatorName>

  
<datacite:givenName>Martin</datacite:givenName>

  
<datacite:familyName>Distel</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-5942-0817</datacite:nameIdentifier>

  
<datacite:affiliation>St. Anna Children&#39;s Cancer Research Institute</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Hermann, Marcela</datacite:creatorName>

  
<datacite:givenName>Marcela</datacite:givenName>

  
<datacite:familyName>Hermann</datacite:familyName>

  
<datacite:affiliation>Medical University of Vienna</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Burger, Pamela A.</datacite:creatorName>

  
<datacite:givenName>Pamela A.</datacite:givenName>

  
<datacite:familyName>Burger</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-6941-0257</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Thaller, Denise</datacite:creatorName>

  
<datacite:givenName>Denise</datacite:givenName>

  
<datacite:familyName>Thaller</datacite:familyName>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Liedvogel, Miriam</datacite:creatorName>

  
<datacite:givenName>Miriam</datacite:givenName>

  
<datacite:familyName>Liedvogel</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-8372-8560</datacite:nameIdentifier>

  
<datacite:affiliation>Max Planck Institute for Evolutionary Biology / Institute of Avian Research</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Bergthaler, Andreas</datacite:creatorName>

  
<datacite:givenName>Andreas</datacite:givenName>

  
<datacite:familyName>Bergthaler</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-0597-1976</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine / Medical University of Vienna</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Skjærven, Kaja</datacite:creatorName>

  
<datacite:givenName>Kaja</datacite:givenName>

  
<datacite:familyName>Skjærven</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-4185-390X</datacite:nameIdentifier>

  
<datacite:affiliation>Norwegian Institute of Marine Research</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Farlik, Matthias</datacite:creatorName>

  
<datacite:givenName>Matthias</datacite:givenName>

  
<datacite:familyName>Farlik</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-0698-2992</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Schmidl, Christian</datacite:creatorName>

  
<datacite:givenName>Christian</datacite:givenName>

  
<datacite:familyName>Schmidl</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-0522-202X</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Fortelny, Nikolaus</datacite:creatorName>

  
<datacite:givenName>Nikolaus</datacite:givenName>

  
<datacite:familyName>Fortelny</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-4025-9968</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Datlinger, Paul</datacite:creatorName>

  
<datacite:givenName>Paul</datacite:givenName>

  
<datacite:familyName>Datlinger</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-7965-2543</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Ergüner, Bekir</datacite:creatorName>

  
<datacite:givenName>Bekir</datacite:givenName>

  
<datacite:familyName>Ergüner</datacite:familyName>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Kirchberger, Stefanie</datacite:creatorName>

  
<datacite:givenName>Stefanie</datacite:givenName>

  
<datacite:familyName>Kirchberger</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0001-6732-3355</datacite:nameIdentifier>

  
<datacite:affiliation>St. Anna Children&#39;s Cancer Research Institute</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Printz, Dieter</datacite:creatorName>

  
<datacite:givenName>Dieter</datacite:givenName>

  
<datacite:familyName>Printz</datacite:familyName>

  
<datacite:affiliation>St. Anna Children&#39;s Cancer Research Institute</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Evankow, Ann</datacite:creatorName>

  
<datacite:givenName>Ann</datacite:givenName>

  
<datacite:familyName>Evankow</datacite:familyName>

  
<datacite:affiliation>Northeastern University</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Kosack, Lindsay</datacite:creatorName>

  
<datacite:givenName>Lindsay</datacite:givenName>

  
<datacite:familyName>Kosack</datacite:familyName>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Lugo Ramos, Juan Sebastian</datacite:creatorName>

  
<datacite:givenName>Juan Sebastian</datacite:givenName>

  
<datacite:familyName>Lugo Ramos</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-3471-3503</datacite:nameIdentifier>

  
<datacite:affiliation>Max Planck Institute for Evolutionary Biology</datacite:affiliation>

  
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<datacite:creator>
  
<datacite:creatorName nameType="Personal">Keinath, Melissa C.</datacite:creatorName>

  
<datacite:givenName>Melissa C.</datacite:givenName>

  
<datacite:familyName>Keinath</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-7313-0215</datacite:nameIdentifier>

  
<datacite:affiliation>University of Kentucky</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Schuster, Linda C.</datacite:creatorName>

  
<datacite:givenName>Linda C.</datacite:givenName>

  
<datacite:familyName>Schuster</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-3470-5490</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Seid, Charlotte A.</datacite:creatorName>

  
<datacite:givenName>Charlotte A.</datacite:givenName>

  
<datacite:familyName>Seid</datacite:familyName>

  
<datacite:affiliation>Northeastern University</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Posautz, Annika</datacite:creatorName>

  
<datacite:givenName>Annika</datacite:givenName>

  
<datacite:familyName>Posautz</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-4924-6733</datacite:nameIdentifier>

  
<datacite:affiliation>University of Veterinary Medicine Vienna</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Romanovskaia, Daria</datacite:creatorName>

  
<datacite:givenName>Daria</datacite:givenName>

  
<datacite:familyName>Romanovskaia</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0003-2831-0919</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
</datacite:creator>

  
<datacite:creator>
  
<datacite:creatorName nameType="Personal">Nemc, Amelie</datacite:creatorName>

  
<datacite:givenName>Amelie</datacite:givenName>

  
<datacite:familyName>Nemc</datacite:familyName>

  
<datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org/">0000-0002-8072-7247</datacite:nameIdentifier>

  
<datacite:affiliation>CeMM Research Center for Molecular Medicine</datacite:affiliation>

  
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<dc:publisher>Nature Portfolio</dc:publisher>

  
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<dc:language>eng</dc:language>

  
<dc:description xml:lang="en">Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been implicated in various regulatory mechanisms across the animal kingdom and particularly in vertebrates. We mapped DNA methylation in 580 animal species (535 vertebrates, 45 invertebrates), resulting in 2443 genome-scale DNA methylation profiles of multiple organs. Bioinformatic analysis of this large dataset quantified the association of DNA methylation with the underlying genomic DNA sequence throughout vertebrate evolution. We observed a broadly conserved link with two major transitions-once in the first vertebrates and again with the emergence of reptiles. Cross-species comparisons focusing on individual organs supported a deeply conserved association of DNA methylation with tissue type, and cross-mapping analysis of DNA methylation at gene promoters revealed evolutionary changes for orthologous genes. In summary, this study establishes a large resource of vertebrate and invertebrate DNA methylomes, it showcases the power of reference-free epigenome analysis in species for which no reference genomes are available, and it contributes an epigenetic perspective to the study of vertebrate evolution.</dc:description>

  
<datacite:subjects>
  
<datacite:subject xml:lang="en">Animals; DNA Methylation Genetics; Genome Genetics; Invertebrates Genetics; Vertebrates Genetics Metabolism; Epigenesis, Genetic; DNA Metabolism</datacite:subject>

  
</datacite:subjects>

  
<licenseCondition uri="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</licenseCondition>

  
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<datacite:alternateIdentifier alternateIdentifierType="DOI">10.1038/s41467-022-34828-y</datacite:alternateIdentifier>

  
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<datacite:relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://phaidra.vetmeduni.ac.at/o:605</datacite:relatedIdentifier>

  
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<dc:format>application/pdf</dc:format>

  
<dc:source>Nature Communications 14(1) (2023)</dc:source>

  
<citationTitle>Nature Communications</citationTitle>

  
<citationVolume>14</citationVolume>

  
<citationIssue>1</citationIssue>

  
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<datacite:dates>
  
<datacite:date dateType="Issued">2023</datacite:date>

  
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