phaidra.vetmeduni.ac.at o:3057 DOI 10.1016/j.isci.2023.108619 Summer fades, deer change: Photoperiodic control of cellular seasonal acclimatization of skeletal muscle We found major seasonal changes of polyunsaturated fatty acids (PUFAs) in muscular phospholipids (PL) in a large non-hibernating mammal, the red deer (Cervus elaphus). Dietary supply of essential linoleic acid (LA) and α-linolenic acid (ALA) had no, or only weak influence, respectively. We further found correlations of PL PUFA concentrations with the activity of key metabolic enzymes, independent of higher winter expression. Activity of the sarcoplasmic reticulum (SR) Ca++-ATPase increased with SR PL concentrations of n-6 PUFA, and of cytochrome c oxidase and citrate synthase, indicators of ATP-production, with concentrations of eicosapentaenoic acid in mitochondrial PL. All detected cyclic molecular changes were controlled by photoperiod and are likely of general relevance for mammals living in seasonal environments, including humans. During winter, these changes at the molecular level presumably compensate for Arrhenius effects in the colder peripheral body parts and thus enable a thrifty life at lower body temperature. eng Fatty-Acid-Composition; Sarcoplasmic-Reticulum Ca2+-Atpase; Carnitine Palmitoyltransferase-I; Adipose-Tissue; Membrane-Function; Acyl Composition; Ca2+ Transport; Rat-Heart; Metabolism; Supplementation 2024-06-03T08:06:35.274Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Gasch;Kristina; FN:Kristina Gasch X-ORCID:https://orcid.org/0000-0001-8760-5210 END:VCARD BEGIN:VCARD VERSION:3.0 N:Arnold;Walter; FN:Walter Arnold X-ORCID:https://orcid.org/0000-0001-6785-5685 END:VCARD BEGIN:VCARD VERSION:3.0 N:Stalder;Gabrielle; FN:Gabrielle Stalder X-ORCID:https://orcid.org/0000-0002-8901-1181 END:VCARD BEGIN:VCARD VERSION:3.0 N:Smith;Steve; FN:Steve Smith X-ORCID:https://orcid.org/0000-0002-1318-0018 END:VCARD BEGIN:VCARD VERSION:3.0 N:Hykollari;Alba; FN:Alba Hykollari X-ORCID:https://orcid.org/0000-0003-3610-2239 END:VCARD BEGIN:VCARD VERSION:3.0 N:Habe;Manuela; FN:Manuela Habe END:VCARD BEGIN:VCARD VERSION:3.0 N:Painer-Gigler;Johanna; FN:Johanna Painer-Gigler X-ORCID:https://orcid.org/0000-0003-3929-511X END:VCARD BEGIN:VCARD VERSION:3.0 N:Haubensak;Patricia; FN:Patricia Haubensak END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by-nc-nd/4.0 application/pdf 4747874 https://phaidra.vetmeduni.ac.at/o:3057 https://phaidra.vetmeduni.ac.at/api/object/o:3057/thumbnail LOMv1.0 discipline