phaidra.vetmeduni.ac.at o:2952 DOI 10.1002/ece3.10886 Genomic signatures of climate adaptation in bank voles Evidence for divergent selection and adaptive variation across the landscape can provide insight into a species' ability to adapt to different environments. However, despite recent advances in genomics, it remains difficult to detect the footprints of climate-mediated selection in natural populations. Here, we analysed ddRAD sequencing data (21,892 SNPs) in conjunction with geographic climate variation to search for signatures of adaptive differentiation in twelve populations of the bank vole (Clethrionomys glareolus) distributed across Europe. To identify the loci subject to selection associated with climate variation, we applied multiple genotype-environment association methods, two univariate and one multivariate, and controlled for the effect of population structure. In total, we identified 213 candidate loci for adaptation, 74 of which were located within genes. In particular, we identified signatures of selection in candidate genes with functions related to lipid metabolism and the immune system. Using the results of redundancy analysis, we demonstrated that population history and climate have joint effects on the genetic variation in the pan-European metapopulation. Furthermore, by examining only candidate loci, we found that annual mean temperature is an important factor shaping adaptive genetic variation in the bank vole. By combining landscape genomic approaches, our study sheds light on genome-wide adaptive differentiation and the spatial distribution of variants underlying adaptive variation influenced by local climate in bank voles. eng Catalytically Inactive Protein; Brown Adipose-Tissue; Local Adaptation; Arabidopsis-Thaliana; Myodes-Glareolus; Clethrionomys-Glareolus; Population-Genetics; Landscape Features; Puumala-Hantavirus; Adaptive Evolution 2024-05-07T13:31:20.707Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Folkertsma;Remco; FN:Remco Folkertsma END:VCARD BEGIN:VCARD VERSION:3.0 N:Eccard;Jana A.; FN:Jana A. Eccard X-ORCID:https://orcid.org/0000-0002-6151-2128 END:VCARD BEGIN:VCARD VERSION:3.0 N:Hofreiter;Michael; FN:Michael Hofreiter END:VCARD BEGIN:VCARD VERSION:3.0 N:Sándor;Attila D.; FN:Attila D. Sándor END:VCARD BEGIN:VCARD VERSION:3.0 N:Plantard;Olivier; FN:Olivier Plantard END:VCARD BEGIN:VCARD VERSION:3.0 N:Paijmans;Johanna L. A.; FN:Johanna L. A. Paijmans END:VCARD BEGIN:VCARD VERSION:3.0 N:Manzo;Emiliano; FN:Emiliano Manzo X-ORCID:https://orcid.org/0000-0001-8861-1559 END:VCARD BEGIN:VCARD VERSION:3.0 N:Kotlík;Petr; FN:Petr Kotlík X-ORCID:https://orcid.org/0000-0001-9429-0667 END:VCARD BEGIN:VCARD VERSION:3.0 N:Huitu;Otso; FN:Otso Huitu END:VCARD BEGIN:VCARD VERSION:3.0 N:Heroldová;Marta; FN:Marta Heroldová END:VCARD BEGIN:VCARD VERSION:3.0 N:Charbonnel;Nathalie; FN:Nathalie Charbonnel END:VCARD BEGIN:VCARD VERSION:3.0 N:Henttonen;Heikki; FN:Heikki Henttonen END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 4125457 https://phaidra.vetmeduni.ac.at/o:2952 https://phaidra.vetmeduni.ac.at/api/object/o:2952/thumbnail LOMv1.0 discipline