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<lom:catalog>phaidra.vetmeduni.ac.at</lom:catalog>

  
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<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.4103/2311-8571.369650</lom:langstring>

  
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<lom:title>
  
<lom:langstring xml:lang="en">Chinese herb formulae inhibit the proliferation of human colon cancer SW480 cells by inducing cell apoptosis</lom:langstring>

  
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<lom:description>
  
<lom:langstring xml:lang="en">Objective: This study aimed to reveal the antitumor effects of Chinese herbal formulae and the underlying mechanisms in treating colorectal cancer, with a focus on developing traditional Chinese medicine (TCM) as a supplement and alternative therapeutic method for cancers. Materials and Methods: Human colon cancer SW480 cells were treated with three Chinese herbal formulae, Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction at different concentrations (50-600 mu g/mL) for 24, 36, and 48 h, respectively. Cell viability was determined using the resazurin reduction assay, and cell survival rate was evaluated using a colony formation assay. After treatment with different concentrations (50-600 mu g/mL) of these three formulae for 48 h, the effects of the Chinese herbal formulae on cell apoptosis were investigated using Hoechst/propidium iodide (PI) staining. The positive PI-stained cells were investigated using an EnSpire multilabel plate reader and the positive Hoechst-stained cells were observed under a fluorescence microscope for morphological changes. Results: Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction inhibited SW480 cell proliferation in a dose-and time-dependent manner and induced cell apoptosis. Conclusion: Chinese herbal formulae with a special prescription form of TCM with antitumor effects bring a new perspective in line with the principles of TCM in cancer treatment.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
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<lom:langstring xml:lang="en">Colorectal-Cancer; Medicine</lom:langstring>

  
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<lom:datetime>2024-03-06T09:55:22.206Z</lom:datetime>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Rausch;Wolf-Dieter;
FN:Wolf-Dieter Rausch
X-ORCID:https://orcid.org/0000-0003-2491-1899
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Fu;Su;
FN:Su Fu
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Qin;Shao-Lin;
FN:Shao-Lin Qin
END:VCARD</lom:vcard>

  
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