o:2526 Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats en Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously. Domestic Cats; 1st Report; Distemper; Lions; Frequency; Kidneys; Lesions; Urine 1552099 10.3390/v15102087 2024-02-14T08:29:14.608Z 44 yes 46 Maria Grazia Pennisi University of Messina 0000-0002-3169-4194 Sándor Belák Swedish University of Agricultural Sciences person 0000-0002-2486-268X Séverine Tasker University of Bristol / Linnaeus Veterinary Limited person 0000-0002-4059-1402 Diane D. Addie person 0000-0001-7843-2661 Corine Boucraut-Baralon Scanelis Laboratory person Herman Egberink University of Utrecht person 0000-0001-6852-5936 Tadeusz Frymus Warsaw University of Life Sciences person 0000-0002-9160-1455 Katrin Hartmann Ludwig Maximilian University of Munich person 0000-0002-5256-863X Regina Hofmann-Lehmann University of Zurich person 0000-0001-9750-4296 Albert Lloret Universitat Autònoma de Barcelona person Fulvio Marsilio Università degli Studi di Teramo person 0000-0001-9552-1199 Etienne Thiry Liège University person 0000-0002-9585-7933 Uwe Truyen University of Leipzig person Karin Möstl University of Veterinary Medicine Vienna person Margaret J. Hosie University of Glasgow person 0000-0002-4313-5023 application/pdf 710304 https://phaidra.vetmeduni.ac.at/o:2526 no yes 16 70 1552253 Viruses 19 15 10 MDPI 2023