https://phaidra.vetmeduni.ac.at/o:2526 Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats Pennisi, Maria Grazia Maria Grazia Pennisi 0000-0002-3169-4194 University of Messina Hosie, Margaret J. Margaret J. Hosie 0000-0002-4313-5023 University of Glasgow Möstl, Karin Karin Möstl University of Veterinary Medicine Vienna Truyen, Uwe Uwe Truyen University of Leipzig Thiry, Etienne Etienne Thiry 0000-0002-9585-7933 Liège University Marsilio, Fulvio Fulvio Marsilio 0000-0001-9552-1199 Università degli Studi di Teramo Lloret, Albert Albert Lloret Universitat Autònoma de Barcelona Hofmann-Lehmann, Regina Regina Hofmann-Lehmann 0000-0001-9750-4296 University of Zurich Hartmann, Katrin Katrin Hartmann 0000-0002-5256-863X Ludwig Maximilian University of Munich Frymus, Tadeusz Tadeusz Frymus 0000-0002-9160-1455 Warsaw University of Life Sciences Egberink, Herman Herman Egberink 0000-0001-6852-5936 University of Utrecht Boucraut-Baralon, Corine Corine Boucraut-Baralon Scanelis Laboratory Addie, Diane D. Diane D. Addie 0000-0001-7843-2661 Belák, Sándor Sándor Belák 0000-0002-2486-268X Swedish University of Agricultural Sciences Tasker, Séverine Séverine Tasker 0000-0002-4059-1402 University of Bristol / Linnaeus Veterinary Limited MDPI text eng Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously. Domestic Cats; 1st Report; Distemper; Lions; Frequency; Kidneys; Lesions; Urine http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:2526/download 10.3390/v15102087 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Viruses 15(10) (2023) Viruses 15 10 693.66 kB 2023