phaidra.vetmeduni.ac.at o:2239 DOI 10.1002/vms3.1151 A genome-wide association study of morphometric traits in dromedaries Investigating genomic regions associated with morphometric traits in camels is valuable, because it allows a better understanding of adaptive and productive features to implement a sustainable management and a customised breeding program for dromedaries.With a genome-wide association study (GWAS) including 96 Iranian dromedaries phenotyped for 12 morphometric traits and genotyped-by-sequencing (GBS) with 14,522 SNPs, we aimed at identifying associated candidate genes.The association between SNPs and morphometric traits was investigated using a linear mixed model with principal component analysis (PCA) and kinship matrix.With this approach, we detected 59 SNPs located in 37 candidate genes potentially associated to morphometric traits in dromedaries. The top associated SNPs were related to pin width, whither to pin length, height at whither, muzzle girth, and tail length. Interestingly, the results highlight the association between whither height, muzzle circumference, tail length, whither to pin length. The identified candidate genes were associated with growth, body size, and immune system in other species.We identified three key hub genes in the gene network analysis including ACTB, SOCS1 and ARFGEF1. In the central position of gene network, ACTB was detected as the most important gene related to muscle function. With this initial GWAS using GBS on dromedary camels for morphometric traits, we show that this SNP panel can be effective for genetic evaluation of growth in dromedaries. However, we suggest a higher-density SNP array may greatly improve the reliability of the results. eng Animals; Genome-Wide Association Studyveterinary; Camelus; Iran; Reproducibility of Results; Phenotype; Polymorphism, Single Nucleotide 2023-10-30T11:32:29.086Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Bitaraf Sani;Morteza; FN:Morteza Bitaraf Sani END:VCARD BEGIN:VCARD VERSION:3.0 N:Naderi;Ali Shafei; FN:Ali Shafei Naderi END:VCARD BEGIN:VCARD VERSION:3.0 N:Kazemi;Ali; FN:Ali Kazemi END:VCARD BEGIN:VCARD VERSION:3.0 N:Zareh Harofteh;Javad; FN:Javad Zareh Harofteh END:VCARD BEGIN:VCARD VERSION:3.0 N:Asadzadeh;Nader; FN:Nader Asadzadeh END:VCARD BEGIN:VCARD VERSION:3.0 N:Mohajer;Mokhtar; FN:Mokhtar Mohajer END:VCARD BEGIN:VCARD VERSION:3.0 N:Roudbari;Zahra; FN:Zahra Roudbari END:VCARD BEGIN:VCARD VERSION:3.0 N:Javanmard;Arash; FN:Arash Javanmard END:VCARD BEGIN:VCARD VERSION:3.0 N:Burger;Pamela Anna; FN:Pamela Anna Burger X-ORCID:https://orcid.org/0000-0002-6941-0257 END:VCARD BEGIN:VCARD VERSION:3.0 N:Karimi;Omid; FN:Omid Karimi END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 937436 https://phaidra.vetmeduni.ac.at/o:2239 https://phaidra.vetmeduni.ac.at/api/object/o:2239/thumbnail LOMv1.0 discipline