phaidra.vetmeduni.ac.at o:2210 DOI 10.3390/vetsci10080494 Litters of Various-Sized Mummies (LVSM) and Stillborns after Porcine Reproductive and Respiratory Syndrome Virus Type 1 Infection-A Case Report Diverse origins and causes are described for papyraceous mummifications of porcine foetuses, but the porcine reproductive and respiratory syndrome virus (PRRSV) is not one of them. In contrast, PRRSV is unlikely to cause mid-term placental transmission but may cause late-term abortions and weakness of piglets. This case report describes a sudden occurrence of mummified foetuses of various sizes and stillborns and delayed birth (>115 days) in more than 50% of sows from one farrowing batch, while newborn piglets were mostly vital. Neither increased embryonic death nor infertility was reported. Three litters with mummies, autolysed piglets and stillborn piglets were investigated, and infections with porcine parvoviruses, porcine teschoviruses, porcine circoviruses, encephalomyocarditis virus, Leptospira spp. and Chlamydia spp. were excluded. Instead, high viral loads of PRRSV were detected in the thymus pools of piglets at all developmental stages, even in piglets with a crown-rump length between 80 and 150 mm, suggesting a potential mid-term in utero transmission of the virus. Genomic regions encoding structural proteins (ORF2-7) of the virus were sequenced and identified the virulent PRRSV-1 strain AUT15-33 as the closest relative. This case report confirms the diversity of PRRSV and its potential involvement in foetal death in mid-gestation. eng Pigs; Failure; Swine; Gilts; Vaccination; Challenge; Prrsv; Sows 2023-10-16T11:52:54.125Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Unterweger;Christine; FN:Christine Unterweger X-ORCID:https://orcid.org/0000-0003-4965-2088 END:VCARD BEGIN:VCARD VERSION:3.0 N:Ladinig;Andrea; FN:Andrea Ladinig X-ORCID:https://orcid.org/0000-0001-5037-7269 END:VCARD BEGIN:VCARD VERSION:3.0 N:Truyen;Uwe; FN:Uwe Truyen END:VCARD BEGIN:VCARD VERSION:3.0 N:Rümenapf;Till; FN:Till Rümenapf X-ORCID:https://orcid.org/0000-0002-2951-7471 END:VCARD BEGIN:VCARD VERSION:3.0 N:Auer;Angelika; FN:Angelika Auer X-ORCID:https://orcid.org/0000-0002-4790-9823 END:VCARD BEGIN:VCARD VERSION:3.0 N:Klingler;Eva; FN:Eva Klingler END:VCARD BEGIN:VCARD VERSION:3.0 N:Kreutzmann;Heinrich; FN:Heinrich Kreutzmann X-ORCID:https://orcid.org/0000-0002-6010-697X END:VCARD BEGIN:VCARD VERSION:3.0 N:Buenger;Moritz; FN:Moritz Buenger X-ORCID:https://orcid.org/0000-0002-7941-8850 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 1401111 https://phaidra.vetmeduni.ac.at/o:2210 https://phaidra.vetmeduni.ac.at/api/object/o:2210/thumbnail LOMv1.0 discipline