https://phaidra.vetmeduni.ac.at/o:2207 Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats Hartmann, Katrin Katrin Hartmann 0000-0002-5256-863X LMU Munich Hosie, Margaret J. Margaret J. Hosie 0000-0002-4313-5023 MRC University of Glasgow Centre for Virus Research Truyen, Uwe Uwe Truyen University of Leipzig Thiry, Etienne Etienne Thiry 0000-0002-9585-7933 Liège University Tasker, Séverine Séverine Tasker 0000-0002-4059-1402 University of Bristol / Linnaeus Veterinary Ltd Pennisi, Maria Grazia Maria Grazia Pennisi 0000-0002-3169-4194 Università di Messina Marsilio, Fulvio Fulvio Marsilio 0000-0001-9552-1199 Università degli Studi di Teramo Hofmann-Lehmann, Regina Regina Hofmann-Lehmann 0000-0001-9750-4296 University of Zurich Lloret, Albert Albert Lloret Universitat Autònoma de Barcelona Frymus, Tadeusz Tadeusz Frymus 0000-0002-9160-1455 Warsaw University of Life Sciences Boucraut-Baralon, Corine Corine Boucraut-Baralon Scanelis Veterinary Test Laboratory Belák, Sándor Sándor Belák 0000-0002-2486-268X Swedish University of Agricultural Sciences Addie, Diane D. Diane D. Addie 0000-0001-7843-2661 Maison Zabal Egberink, Herman Herman Egberink 0000-0001-6852-5936 University of Utrecht Möstl, Karin Karin Möstl University of Veterinary Medicine Vienna MDPI text eng Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential. Cats; Animals; Vaccinationadverse effectsveterinary; Sarcomaetiologyveterinary; Cat Diseasesetiology; Commerce; Inflammation http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:2207/download 10.3390/v15081708 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Viruses 15(8) (2023) Viruses 15 8 1.13 MB 2023