phaidra.vetmeduni.ac.at o:2207 DOI 10.3390/v15081708 Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential. eng Cats; Animals; Vaccinationadverse effectsveterinary; Sarcomaetiologyveterinary; Cat Diseasesetiology; Commerce; Inflammation 2023-10-16T08:55:36.594Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Hartmann;Katrin; FN:Katrin Hartmann X-ORCID:https://orcid.org/0000-0002-5256-863X END:VCARD BEGIN:VCARD VERSION:3.0 N:Hosie;Margaret J.; FN:Margaret J. Hosie X-ORCID:https://orcid.org/0000-0002-4313-5023 END:VCARD BEGIN:VCARD VERSION:3.0 N:Truyen;Uwe; FN:Uwe Truyen END:VCARD BEGIN:VCARD VERSION:3.0 N:Thiry;Etienne; FN:Etienne Thiry X-ORCID:https://orcid.org/0000-0002-9585-7933 END:VCARD BEGIN:VCARD VERSION:3.0 N:Tasker;Séverine; FN:Séverine Tasker X-ORCID:https://orcid.org/0000-0002-4059-1402 END:VCARD BEGIN:VCARD VERSION:3.0 N:Pennisi;Maria Grazia; FN:Maria Grazia Pennisi X-ORCID:https://orcid.org/0000-0002-3169-4194 END:VCARD BEGIN:VCARD VERSION:3.0 N:Marsilio;Fulvio; FN:Fulvio Marsilio X-ORCID:https://orcid.org/0000-0001-9552-1199 END:VCARD BEGIN:VCARD VERSION:3.0 N:Hofmann-Lehmann;Regina; FN:Regina Hofmann-Lehmann X-ORCID:https://orcid.org/0000-0001-9750-4296 END:VCARD BEGIN:VCARD VERSION:3.0 N:Lloret;Albert; FN:Albert Lloret END:VCARD BEGIN:VCARD VERSION:3.0 N:Frymus;Tadeusz; FN:Tadeusz Frymus X-ORCID:https://orcid.org/0000-0002-9160-1455 END:VCARD BEGIN:VCARD VERSION:3.0 N:Boucraut-Baralon;Corine; FN:Corine Boucraut-Baralon END:VCARD BEGIN:VCARD VERSION:3.0 N:Belák;Sándor; FN:Sándor Belák X-ORCID:https://orcid.org/0000-0002-2486-268X END:VCARD BEGIN:VCARD VERSION:3.0 N:Addie;Diane D.; FN:Diane D. Addie X-ORCID:https://orcid.org/0000-0001-7843-2661 END:VCARD BEGIN:VCARD VERSION:3.0 N:Egberink;Herman; FN:Herman Egberink X-ORCID:https://orcid.org/0000-0001-6852-5936 END:VCARD BEGIN:VCARD VERSION:3.0 N:Möstl;Karin; FN:Karin Möstl END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 1182819 https://phaidra.vetmeduni.ac.at/o:2207 https://phaidra.vetmeduni.ac.at/api/object/o:2207/thumbnail LOMv1.0 discipline