o:1981 Calicivirus Infection in Cats en Feline calicivirus (FCV) is a common pathogen in domestic cats that is highly contagious, resistant to many disinfectants and demonstrates a high genetic variability. FCV infection can lead to serious or even fatal diseases. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European countries, presents the current knowledge of FCV infection and fills gaps with expert opinions. FCV infections are particularly problematic in multicat environments. FCV-infected cats often show painful erosions in the mouth and mild upper respiratory disease and, particularly in kittens, even fatal pneumonia. However, infection can be associated with chronic gingivostomatitis. Rarely, highly virulent FCV variants can induce severe systemic disease with epizootic spread and high mortality. FCV can best be detected by reverse-transcriptase PCR. However, a negative result does not rule out FCV infection and healthy cats can test positive. All cats should be vaccinated against FCV (core vaccine); however, vaccination protects cats from disease but not from infection. Considering the high variability of FCV, changing to different vaccine strain(s) may be of benefit if disease occurs in fully vaccinated cats. Infection-induced immunity is not life-long and does not protect against all strains; therefore, vaccination of cats that have recovered from caliciviral disease is recommended. Recombinant Feline Interferon; Virulent Systemic-Disease; Respiratory-Tract Disease; Quasi-Species Evolution; Chain-Reaction Assay; Capsid Protein; Hypervariable Region; Genetic Diversity; Molecular Characterization; Chronic Gingivostomatitis 1552099 10.3390/v14050937 2023-08-14T09:06:57.080Z 44 yes 46 Regina Hofmann-Lehmann University of Zurich 0000-0001-9750-4296 Karin Möstl University of Veterinary Medicine Vienna person Alan D. Radford University of Liverpool person Etienne Thiry Liège University person 0000-0002-9585-7933 Hans Lutz University of Zurich person Diane D. Addie University of Glasgow person 0000-0001-7843-2661 Maria Grazia Pennisi Università di Messina person Fulvio Marsilio Università degli Studi di Teramo person 0000-0001-9552-1199 Albert Lloret Universitat Autònoma de Barcelona person Tadeusz Frymus Warsaw University of Life Sciences person 0000-0002-9160-1455 Corine Boucraut-Baralon Scanelis Laboratory person Sándor Belák Swedish University of Agricultural Sciences person Séverine Tasker University of Bristol / Linnaeus Veterinary Limited person 0000-0002-4059-1402 Uwe Truyen University of Leipzig person Herman Egberink University of Utrecht person 0000-0001-6852-5936 Katrin Hartmann Ludwig Maximilian University Munich person 0000-0002-5256-863X Margaret J. Hosie University of Glasgow person 0000-0002-4313-5023 application/pdf 921887 https://phaidra.vetmeduni.ac.at/o:1981 no yes 16 70 1552253 Viruses 31 14 5 MDPI 2022