https://phaidra.vetmeduni.ac.at/o:1981 Calicivirus Infection in Cats Hofmann-Lehmann, Regina Regina Hofmann-Lehmann 0000-0001-9750-4296 University of Zurich Möstl, Karin Karin Möstl University of Veterinary Medicine Vienna Radford, Alan D. Alan D. Radford University of Liverpool Thiry, Etienne Etienne Thiry 0000-0002-9585-7933 Liège University Lutz, Hans Hans Lutz University of Zurich Addie, Diane D. Diane D. Addie 0000-0001-7843-2661 University of Glasgow Pennisi, Maria Grazia Maria Grazia Pennisi Università di Messina Marsilio, Fulvio Fulvio Marsilio 0000-0001-9552-1199 Università degli Studi di Teramo Lloret, Albert Albert Lloret Universitat Autònoma de Barcelona Frymus, Tadeusz Tadeusz Frymus 0000-0002-9160-1455 Warsaw University of Life Sciences Boucraut-Baralon, Corine Corine Boucraut-Baralon Scanelis Laboratory Belák, Sándor Sándor Belák Swedish University of Agricultural Sciences Tasker, Séverine Séverine Tasker 0000-0002-4059-1402 University of Bristol / Linnaeus Veterinary Limited Truyen, Uwe Uwe Truyen University of Leipzig Egberink, Herman Herman Egberink 0000-0001-6852-5936 University of Utrecht Hartmann, Katrin Katrin Hartmann 0000-0002-5256-863X Ludwig Maximilian University Munich Hosie, Margaret J. Margaret J. Hosie 0000-0002-4313-5023 University of Glasgow MDPI text eng Feline calicivirus (FCV) is a common pathogen in domestic cats that is highly contagious, resistant to many disinfectants and demonstrates a high genetic variability. FCV infection can lead to serious or even fatal diseases. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European countries, presents the current knowledge of FCV infection and fills gaps with expert opinions. FCV infections are particularly problematic in multicat environments. FCV-infected cats often show painful erosions in the mouth and mild upper respiratory disease and, particularly in kittens, even fatal pneumonia. However, infection can be associated with chronic gingivostomatitis. Rarely, highly virulent FCV variants can induce severe systemic disease with epizootic spread and high mortality. FCV can best be detected by reverse-transcriptase PCR. However, a negative result does not rule out FCV infection and healthy cats can test positive. All cats should be vaccinated against FCV (core vaccine); however, vaccination protects cats from disease but not from infection. Considering the high variability of FCV, changing to different vaccine strain(s) may be of benefit if disease occurs in fully vaccinated cats. Infection-induced immunity is not life-long and does not protect against all strains; therefore, vaccination of cats that have recovered from caliciviral disease is recommended. Recombinant Feline Interferon; Virulent Systemic-Disease; Respiratory-Tract Disease; Quasi-Species Evolution; Chain-Reaction Assay; Capsid Protein; Hypervariable Region; Genetic Diversity; Molecular Characterization; Chronic Gingivostomatitis http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:1981/download 10.3390/v14050937 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Viruses 14(5) (2022) Viruses 14 5 900.28 kB 2022