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<lom:catalog>phaidra.vetmeduni.ac.at</lom:catalog>

  
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<lom:langstring xml:lang="x-none">o:1975</lom:langstring>

  
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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.2147/OTT.S351500</lom:langstring>

  
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</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">Protein Expression of Folate Receptor Alpha in Adenoid Cystic Carcinoma of the Head and Neck</lom:langstring>

  
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<lom:description>
  
<lom:langstring xml:lang="en">Abstract: Folate receptor alpha (FRα) is overexpressed in various cancer entities while expression in normal tissue is limited. Thus, FRα is an attractive target in cancer therapy. Currently, various therapeutic and diagnostic approaches are under investigation in clinical trials. The aim of this study was to assess the expression and clinical relevance of FRα in adenoid cystic carcinoma of the head and neck.In this retrospective cohort study, 43 patients with adenoid cystic carcinoma (ACC) of the head and neck were included. FRα expression was analyzed in tumor tissue and tumor-free margin in a tissue microarray using immunohistochemical staining. Protein levels were correlated with clinical parameters.FRα staining was positive in 47% of ACC patients. The tumor-free margin was positive in 22%. Patients with positive tumor tissue showed positive margin staining in 55%. FRα expression was not associated with the clinical parameters (sex, age, staging, grading, perineural invasion, lymphovascular invasion).FRα expression is common in ACC of the head and neck. Therefore, FRα should be further evaluated as a therapeutic target in ACC.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="de">Antibody-Drug Conjugate; Mirvetuximab Soravtansine; Ovarian-Carcinoma; Phase-Iii; Chemotherapy; Combination; Trial</lom:langstring>

  
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<lom:datetime>2023-08-11T08:06:36.972Z</lom:datetime>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Schnoell;Julia;
FN:Julia Schnoell
X-ORCID:https://orcid.org/0000-0001-9772-4395
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Kenner;Lukas;
FN:Lukas Kenner
X-ORCID:https://orcid.org/0000-0003-2184-1338
END:VCARD</lom:vcard>

  
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Heiduschka;Gregor;
FN:Gregor Heiduschka
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Schlederer;Michaela;
FN:Michaela Schlederer
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N:Gurnhofer;Elisabeth;
FN:Elisabeth Gurnhofer
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N:Stoiber;Stefan;
FN:Stefan Stoiber
END:VCARD</lom:vcard>

  
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VERSION:3.0
N:Kadletz-Wanke;Lorenz;
FN:Lorenz Kadletz-Wanke
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Jank;Bernhard J.;
FN:Bernhard J. Jank
END:VCARD</lom:vcard>

  
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