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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1038/s41598-022-09714-8</lom:langstring>

  
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</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">The transcriptome from asexual to sexual in vitro development of Cystoisospora suis (Apicomplexa: Coccidia)</lom:langstring>

  
</lom:title>

  
<lom:description>
  
<lom:langstring xml:lang="en">The apicomplexan parasite Cystoisospora suis is an enteropathogen of suckling piglets with woldwide distribution. As with all coccidian parasites, its lifecycle is characterized by asexual multiplication followed by sexual development with two morphologically distinct cell types that presumably fuse to form a zygote from which the oocyst arises. However, knowledge of the sexual development of C. suis is still limited. To complement previous in vitro studies, we analysed transcriptional profiles at three different time points of development (corresponding to asexual, immature and mature sexual stages) in vitro via RNASeq. Overall, transcription of genes encoding proteins with important roles in gametes biology, oocyst wall biosynthesis, DNA replication and axonema formation as well as proteins with important roles in merozoite biology was identified. A homologue of an oocyst wall tyrosine rich protein of Toxoplasma gondii was expressed in macrogametes and oocysts of C. suis. We evaluated inhibition of sexual development in a host-free culture for C. suis by antiserum specific to this protein to evaluate whether it could be exploited as a candidate for control strategies against C. suis. Based on these data, targets can be defined for future strategies to interrupt parasite transmission during sexual development.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Toxoplasma-Gondii; Oocyst Wall; Eimeria-Maxima; Gliding Motility; Cryptosporidium-Parvum; Plasmodium-Berghei; Gene-Expression; Quality-Control; Cross-Linking; Life-Cycle</lom:langstring>

  
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<lom:datetime>2023-07-21T09:20:35.191Z</lom:datetime>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Cruz-Bustos;Teresa;
FN:Teresa Cruz-Bustos
X-ORCID:https://orcid.org/0000-0002-6976-4354
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Joachim;Anja;
FN:Anja Joachim
X-ORCID:https://orcid.org/0000-0003-3082-6885
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
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N:Ruttkowski;Bärbel;
FN:Bärbel Ruttkowski
END:VCARD</lom:vcard>

  
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
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N:Dolezal;Marlies;
FN:Marlies Dolezal
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<lom:vcard>BEGIN:VCARD
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N:Lyrakis;Manolis;
FN:Manolis Lyrakis
X-ORCID:https://orcid.org/0000-0003-2768-3844
END:VCARD</lom:vcard>

  
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Feix;Anna Sophia;
FN:Anna Sophia Feix
X-ORCID:https://orcid.org/0000-0001-5068-2546
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