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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1126/sciadv.abk3338</lom:langstring>

  
</lom:entry>

  
</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer</lom:langstring>

  
</lom:title>

  
<lom:description>
  
<lom:langstring xml:lang="en">The tumor-suppressor PTPN2 is diminished in a subset of triple-negative breast cancers (TNBCs). Paradoxically, PTPN2-deficiency in tumors or T cells in mice can facilitate T cell recruitment and/or activation to promote antitumor immunity. Here, we explored the therapeutic potential of targeting PTPN2 in tumor cells and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival. PTPN2 deletion in murine mammary epithelial cells TNBC models, did not promote tumorigenicity but increased STAT-1-dependent T cell recruitment and PD-L1 expression to repress tumor growth and enhance the efficacy of anti-PD-1. Furthermore, the combined deletion of PTPN2 in tumors and T cells facilitated T cell recruitment and activation and further repressed tumor growth or ablated tumors already predominated by exhausted T cells. Thus, PTPN2-targeting in tumors and/or T cells facilitates T cell recruitment and/or alleviates inhibitory constraints on T cells to combat TNBC.</lom:langstring>

  
</lom:description>

  
<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Protein-Tyrosine-Phosphatase; Tumor-Infiltrating Lymphocytes; Mediated Gene Deletion; Activation; Promotes; Obesity; Stat1; Expression; Generation; Relevance</lom:langstring>

  
</lom:keyword>

  
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<lom:lifecycle>
  
<lom:datetime>2023-07-03T12:52:03.957Z</lom:datetime>

  
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<lom:langstring xml:lang="x-none">LOMv1.0</lom:langstring>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Goh;Pei Kee;
FN:Pei Kee Goh
X-ORCID:https://orcid.org/0000-0001-9404-6058
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:McLean;Catriona;
FN:Catriona McLean
X-ORCID:https://orcid.org/0000-0002-0302-5727
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
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N:Tiganis;Tony;
FN:Tony Tiganis
X-ORCID:https://orcid.org/0000-0002-8065-9942
END:VCARD</lom:vcard>

  
</lom:centity>

  
<lom:centity>
  
<lom:vcard>BEGIN:VCARD
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N:Humbert;Patrick O.;
FN:Patrick O. Humbert
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END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Müller;Mathias;
FN:Mathias Müller
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Loi;Sherene;
FN:Sherene Loi
X-ORCID:https://orcid.org/0000-0001-6137-9171
END:VCARD</lom:vcard>

  
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VERSION:3.0
N:Xu;Rachel;
FN:Rachel Xu
END:VCARD</lom:vcard>

  
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<lom:centity>
  
<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Goode;Nathan;
FN:Nathan Goode
X-ORCID:https://orcid.org/0000-0002-3413-407X
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Molloy;Tim;
FN:Tim Molloy
END:VCARD</lom:vcard>

  
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VERSION:3.0
N:Britt;Kara L.;
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X-ORCID:https://orcid.org/0000-0002-0359-505X
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Zeissig;Mara N.;
FN:Mara N. Zeissig
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Wiede;Florian;
FN:Florian Wiede
X-ORCID:https://orcid.org/0000-0001-5145-7180
END:VCARD</lom:vcard>

  
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<lom:location>https://phaidra.vetmeduni.ac.at/o:1787</lom:location>

  
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