https://phaidra.vetmeduni.ac.at/o:1512 Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL-AmpC Producing E. coli as An Example-Challenges and Perspectives Perestrelo, Sara Sara Perestrelo 0000-0002-8370-7911 German Federal Institute for Risk Assessment Alvarez, Julio Julio Alvarez 0000-0002-8999-9417 Universidad Complutense Burgess, Catherine Catherine Burgess 0000-0003-3722-5935 Teagasc Food Research Centre Ashtown Zając, Magdalena Magdalena Zając 0000-0002-8155-7614 National Veterinary Research Institute Veldman, Kees T. Kees T. Veldman Slowey, Rosemarie Rosemarie Slowey Backweston Laboratory Campus Skarżyńska, Magdalena Magdalena Skarżyńska 0000-0001-5666-9510 National Veterinary Research Institute Silveira, Leonor Leonor Silveira National Institute of Health Doutor Ricardo Jorge Pista, Angela Angela Pista 0000-0002-9219-4222 National Institute of Health Doutor Ricardo Jorge Prendergast, Deirdre Deirdre Prendergast Backweston Laboratory Campus Morris, Dearbháile Dearbháile Morris University of Galway Lopez-Chavarrias, Vicente Vicente Lopez-Chavarrias 0000-0002-3558-9260 Universidad Complutense Karpíšková, Renata Renata Karpíšková Masaryk University Kaesbohrer, Annemarie Annemarie Kaesbohrer 0000-0003-2966-2713 University of Veterinary Medicine, Vienna / German Federal Institute for Risk Assessment Ribeiro Duarte, Ana Sofia Ana Sofia Ribeiro Duarte 0000-0002-8794-0542 Technical University of Denmark Clemente, Lurdes Lurdes Clemente 0000-0003-2064-2046 National Institute of Agrarian and Veterinary Research Brouwer, Michael S M Michael S M Brouwer Amaro, Ana Ana Amaro 0000-0002-5139-3268 National Institute of Agrarian and Veterinary Research MDPI text eng Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here. Resistant Escherichia-Coli; Spectrum Beta-Lactamase; Antimicrobial Resistance; Antibiotic-Resistance; Enterobacteriaceae; Animals; Food; Environment; Prevalence; Carriage http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:1512/download 10.3390/antibiotics12030552 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Antibiotics 12(3) (2023) Antibiotics 12 3 443.44 kB 2023