University of Veterinary Medicine Vienna Interventions to Reduce Risk for Pathogen Spillover and Early Disease Spread to Prevent Outbreaks, Epidemics, and Pandemics The pathogens that cause most emerging infectious diseases in humans originate in animals, particularly wildlife, and then spill over into humans. The accelerating frequency with which humans and domestic animals encounter wildlife because of activities such as land-use change, animal husbandry, and markets and trade in live wildlife has created growing opportunities for pathogen spillover. The risk of pathogen spillover and early disease spread among domestic animals and humans, however, can be reduced by stopping the clearing and degradation of tropical and subtropical forests, improving health and economic security of communities living in emerging infectious disease hotspots, enhancing biosecurity in animal husbandry, shutting down or strictly regulating wildlife markets and trade, and expanding pathogen surveillance. We summarize expert opinions on how to implement these goals to prevent outbreaks, epidemics, and pandemics. en TEXT article 2023 2023 Vora, Neil M Sizer, Nigel C Bonds, Matthew H Evans, Jo Chilukuri, Bhavana Cook, Sonila Epstein, Jonathan H Hannah, Lee Walzer, Chris (University of Veterinary Medicine Vienna) Vale, Mariana M Lieberman, Susan Emerson, Ashley Jennings, Jonathan Alders, Robyn Centers for Disease Control and Prevention